| Gene Symbol | FLOT2 |
|---|---|
| Entrez Gene | 2319 |
| Alt Symbol | ECS-1, ECS1, ESA, ESA1, M17S1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | flotillin 2 |
| Other Description | Flotillin 2 (epidermal surface antigen 1)|epidermal surface antigen|flotillin-2|membrane component chromosome 17 surface marker 1|membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1) |
| Swissprots | Q14254 |
| Accessions | EAW51152 EAW51154 EAW51155 EAW51158 EAW51161 EAW51162 Q14254 AK225491 BC003683 AAH03683 BC017292 AAH17292 BT019477 AAV38284 BT019478 AAV38285 CA390100 CR541784 CAG46583 CR542265 CAG47061 DQ892691 ABM83617 DQ895935 ABM86861 M60922 AAA65729 XM_005257950 XP_005258007 XM_005257952 XP_005258009 XM_005257953 XP_005258010 NM_004475 NP_004466 |
| Function | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:20682791}; Peripheral membrane protein {ECO:0000269|PubMed:20682791}. Membrane, caveola {ECO:0000269|PubMed:20682791}; Peripheral membrane protein {ECO:0000269|PubMed:20682791}. Endosome {ECO:0000269|PubMed:20682791}. Note=Membrane-associated protein of caveolae. |
| Tissue Specificity | In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes. |
| Top Pathways | Insulin signaling pathway |