| Gene Symbol |
ARL4C
|
| Entrez Gene |
10123
|
| Alt Symbol |
ARL7, LAK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ADP-ribosylation factor-like 4C
|
| Other Description |
ADP ribosylation factor-like protein 7|ADP-ribosylation factor-like 7|ADP-ribosylation factor-like protein 4C|ADP-ribosylation factor-like protein 7|ADP-ribosylation factor-like protein LAK
|
| Swissprots |
Q53R10 P56559 Q9BVN1 Q9UQ34 Q4A519
|
| Accessions |
AAX93114 CBX53831 EAW71073 EAW71074 P56559 AB016811 BAA75473 AF493892 AAM12606 AJ579850 CAE30322 AJ579851 CAE30323 AK314119 BAG36810 BC001051 BC089043 AAH89043 BM541491 BM904613 BT019378 AAV38185 BT019379 AAV38186 BU844902 CA413100 CD358707 EU832169 ACE87519 EU832263 ACE86833 Y17804 CAB44355 NM_001282431 NP_001269360 NM_005737 NP_005728
|
| Function |
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP- bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process. {ECO:0000269|PubMed:15147902, ECO:0000269|PubMed:17398095, ECO:0000269|PubMed:19409876}.
|
| Subcellular Location |
Cell projection, filopodium. Cell membrane. Cytoplasm.
|
| Tissue Specificity |
Expressed in several tumor cell lines (at protein level). Expressed in lung, brain, leukocytes and placenta. {ECO:0000269|PubMed:19409876}.
|
![Western Blot: ARL4C Overexpression Lysate (Adult Normal) [NBP2-07712] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ARL4C.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8534_ARL4C%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07712-img0001.jpg)