Gene Symbol | Neurog3 |
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Entrez Gene | 11925 |
Alt Symbol | Atoh5, Math4B, bHLHa7, ngn3 |
Species | Mouse |
Gene Type | protein-coding |
Description | neurogenin 3 |
Other Description | NGN-3|Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B)|atonal homolog 5|helix-loop-helix protein mATH-4B|neurogenin-3|protein atonal homolog 5 |
Swissprots | P70661 |
Accessions | AAC53029 AAK50058 CAA70366 EDL32112 EDL32113 P70661 AK008017 BAB25411 BC104326 AAI04327 BC104327 AAI04328 NM_009719 NP_033849 |
Function | Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types. {ECO:0000269|PubMed:10677506, ECO:0000269|PubMed:19759004}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}. |
Top Pathways | Maturity onset diabetes of the young |
Neurogenin 3 CRISPR/Cas9 KO Plasmid (m) - sc-419234 from Santa Cruz Biotechnology
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Neurogenin 3 HDR Plasmid (m) - sc-419234-HDR from Santa Cruz Biotechnology
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Neurogenin 3 Double Nickase Plasmid (m) - sc-419234-NIC from Santa Cruz Biotechnology
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Neurogenin 3 Double Nickase Plasmid (m2) - sc-419234-NIC-2 from Santa Cruz Biotechnology
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Neurogenin 3 CRISPR Activation Plasmid (m) - sc-419234-ACT from Santa Cruz Biotechnology
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Neurogenin 3 CRISPR Activation Plasmid (m2) - sc-419234-ACT-2 from Santa Cruz Biotechnology
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Neurogenin 3 Lentiviral Activation Particles (m) - sc-419234-LAC from Santa Cruz Biotechnology
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Neurogenin 3 Lentiviral Activation Particles (m2) - sc-419234-LAC-2 from Santa Cruz Biotechnology
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Neurogenin 3 siRNA (m) - sc-42080 from Santa Cruz Biotechnology
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Neurogenin 3 shRNA Plasmid (m) - sc-42080-SH from Santa Cruz Biotechnology
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Neurogenin 3 shRNA (m) Lentiviral Particles - sc-42080-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU010391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN36384 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36384 from Sigma-Aldrich
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NEUROG3 siRNA (Mouse) - CRM0290 from Cohesion Biosciences
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shRNA set against Mouse NEUROG3 (NM_009719.6) - SHH351628 from Creative biogene
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Neurogenin 3 CRISPR/Cas9 KO Plasmid (m2) - sc-419234-KO-2 from Santa Cruz Biotechnology
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Neurogenin 3 HDR Plasmid (m2) - sc-419234-HDR-2 from Santa Cruz Biotechnology
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NEUROG3 shRNA Plasmid (Mouse) - CHM0290 from Cohesion Biosciences
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NEUROG3 miRNA 3'UTR clone - MiUTR1M-07617 from Creative biogene
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