| Gene Symbol | LGALS1 |
|---|---|
| Entrez Gene | 3956 |
| Alt Symbol | GAL1, GBP |
| Species | Human |
| Gene Type | protein-coding |
| Description | lectin, galactoside-binding, soluble, 1 |
| Other Description | 14 kDa laminin-binding protein|14 kDa lectin|HBL|HLBP14|HPL|S-Lac lectin 1|beta-galactoside-binding lectin L-14-I|beta-galactoside-binding protein 14kDa|gal-1|galaptin|galectin 1|galectin-1|lactose-binding lectin 1|putative MAPK-activating protein PM12 |
| Swissprots | B2R5E8 P09382 Q9UDK5 |
| Accessions | AAB00777 CAX48935 CBX53893 EAW60178 P09382 AB097036 BAC77389 AK312161 BAG35095 AL832117 AM392658 CAL37536 BC001693 AAH01693 BC020675 AAH20675 BT006775 AAP35421 CR456511 CAG30397 CU013110 CAK54541 CU013398 CAK54840 D28452 BAA05818 DQ892263 ABM83189 DQ895465 ABM86391 EU363770 ACA58297 J04456 AAA36170 LN607840 CEF49527 S44881 AAB19412 X14829 CAA32938 X15256 CAA33328 NM_002305 NP_002296 |
| Function | May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. {ECO:0000269|PubMed:14617626, ECO:0000269|PubMed:18796645, ECO:0000269|PubMed:19497882}. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:14617626}. |
| Tissue Specificity | Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells. {ECO:0000269|PubMed:18824694, ECO:0000269|PubMed:19497882}. |