| Gene Symbol |
FOXM1
|
| Entrez Gene |
2305
|
| Alt Symbol |
FKHL16, FOXM1B, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2, MPP2, PIG29, TGT3, TRIDENT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
forkhead box M1
|
| Other Description |
Forkhead, drosophila, homolog-like 16|HNF-3/fork-head homolog 11|M-phase phosphoprotein 2|MPM-2 reactive phosphoprotein 2|forkhead box protein M1|forkhead-related protein FKHL16|hepatocyte nuclear factor 3 forkhead homolog 11|transcription factor Trident|winged-helix factor from INS-1 cells
|
| Swissprots |
Q4ZGG7 O43260 Q08050 O43259 O43258 Q9BRL2
|
| Accessions |
AAY26401 CAJ34550 CAP58600 CCD32724 CQB48380 CQB48381 CQB48382 EAW88880 EAW88881 EAW88882 EAW88883 Q08050 AK291206 BAF83895 AK313845 AW780338 AY542306 AAT08175 BC006192 AAH06192 BC006529 AAH06529 BC012863 AAH12863 BC035437 BQ229497 BT006986 AAP35632 DB137846 JF432495 ADZ15712 L16783 AAC37541 U74612 AAC51128 U74613 AAC51129 U83113 AAC63595 XM_005253676 XP_005253733 XM_011520930 XP_011519232 XM_011520931 XP_011519233 XM_011520932 XP_011519234 XM_011520933 XP_011519235 XM_011520934 XP_011519236 XM_011520935 XP_011519237 XR_931507 NM_001243088 NP_001230017 NM_001243089 NP_001230018 NM_021953 NP_068772 NM_202002 NP_973731 NM_202003 NP_973732
|
| Function |
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.
|