| Gene Symbol |
NCF2
|
| Entrez Gene |
4688
|
| Alt Symbol |
NCF-2, NOXA2, P67-PHOX, P67PHOX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neutrophil cytosolic factor 2
|
| Other Description |
67 kDa neutrophil oxidase factor|NADPH oxidase activator 2|chronic granulomatous disease, autosomal 2|neutrophil NADPH oxidase factor 2|neutrophil cytosol factor 2|neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2)
|
| Swissprots |
E9PHJ2 E9PHX3 Q9BV51 P19878 B4DKQ7 Q2PP06 B2R6Q1 B4DQA7 Q8NFC7
|
| Accessions |
AAB60320 ABC40738 ABG74586 EAW91160 EAW91161 EAW91162 P19878 AB209647 BAD92884 AF527950 AAM89263 AK296672 BAG59269 AK298713 BAG60869 AK312666 BAG35548 AW951155 BC001606 AAH01606 BM979513 BP193903 BQ029626 BT007439 AAP36107 BU617086 DA420141 DA817767 DC358267 DQ893650 ABM84576 DQ895812 ABM86738 M32011 AAA36379 XM_005245207 XP_005245264 XM_011509580 XP_011507882 XM_011509581 XP_011507883 XR_921801 NM_000433 NP_000424 NM_001127651 NP_001121123 NM_001190789 NP_001177718 NM_001190794 NP_001177723
|
| Function |
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000269|PubMed:12207919}.
|
| Subcellular Location |
Cytoplasm.
|
| Top Pathways |
Leukocyte transendothelial migration, Leishmaniasis, Phagosome, Osteoclast differentiation
|