RAD1

Gene Symbol	RAD1
Entrez Gene	5810
Alt Symbol	HRAD1, REC1
Species	Human
Gene Type	protein-coding
Description	RAD1 checkpoint DNA exonuclease
Other Description	DNA repair exonuclease REC1|DNA repair exonuclease rad1 homolog|RAD1 homolog|cell cycle checkpoint protein Hrad1|cell cycle checkpoint protein RAD1|checkpoint control protein HRAD1|exonuclease homolog RAD1|rad1-like DNA damage checkpoint protein
Swissprots	Q1W161 Q5KSM0 O95304 O60671 Q9UEP1 Q5KSM1 O75572
Accessions	ABD96829 BAD86789 BAD86790 EAW55903 EAW55904 EAW55906 EAW55907 EAW55908 O60671 AF011905 AAC27243 AF030933 AAC95427 AF058392 AAC14138 AF058393 AF073524 AAC95466 AF074717 AAC98093 AF076841 AAC95523 AF084512 AAC35549 AF084513 AAC35550 AF090170 AAC95603 AJ004974 CAA06248 AJ004975 CAA06249 AK002112 BAG51017 AK096960 BC006837 AAH06837 BC009804 AAH09804 BC035771 BC037857 AAH37857 BT006908 AAP35554 DQ891144 ABM82070 DQ894324 ABM85250 NM_002853 NP_002844 NR_026591 NM_001033673 NM_133282 NM_133377
Function	Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity. {ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:9660799}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:9716408}.
Tissue Specificity	Expressed in testis, uterus, bladder, spleen, ovaries, lung, brain and muscle (at protein level). {ECO:0000269|PubMed:9716408}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Rad1 full length protein - ab97946 from Abcam Category Protein Source E. coli Species Human

Human Rad1 full length protein - ab123485 from Abcam Category Protein Source E. coli Species Human

RAD1-Antibody-Center-Blocking-Peptide - BP16013c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RAD1 Protein (OPPA02352) - OPPA02352 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

RAD1 (1-282, His-tag) - AR09582PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

RAD1 (1-282, His-tag) - AR09582PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

RAD1 - H00005810-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RAD1 - H00005810-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RAD1 - H00005810-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RAD1 - H00005810-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RAD1, 1-282aa, Human, His tag, E.coli - 01-1895-1 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

RAD1 fusion protein - Ag2316 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RAD1 Human - PRPS-875 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant human RAD1 Protein - BP003007-PRO-868 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

RAD1, 1-282aa, Recombinant Protein - GWB-P1393B from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

Recombinant Human RAD1 Homolog (S. pombe), His-tagged - RAD1-2756H from Creative Biomart Category Protein Source E.coli.

Recombinant Human RAD1, His-tagged - RAD1-31287TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human RAD1, GST-tagged - RAD1-2151H from Creative Biomart Category Protein Source E.coli Species Human

RAD1 - NKX-424 from Reagent Proteins Category Protein Prices $364.00, $5,334.00 Sizes 10.00 µg, 1 mg Source E.coli

RAD1 1-282aa - CMB-478 from Reagent Proteins Category Protein Prices $539.00, $1,099.00 Sizes 50.00 µg, 250.00 µg Source E.coli Species Human

RAD1 Blocking Peptide - CBP3001 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Human Cell cycle checkpoint protein RAD1(RAD1) - CSB-YP019252HU CSB-EP019252HU CSB-BP019252HU CSB-MP019252HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RAD1, 1-282aa, Human, His tag, E.coli - ATGP0645 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

RAD1 Protein - abx164993 from Abbexa Category Protein Species Human, Mouse, Rat

RAD1 (transcript variant 1) - TP316420 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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