CACNA1C

Gene Symbol	CACNA1C
Entrez Gene	775
Alt Symbol	CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, TS
Species	Human
Gene Type	protein-coding
Description	calcium channel, voltage-dependent, L type, alpha 1C subunit
Other Description	DHPR, alpha-1 subunit|calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle|calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit|voltage-dependent L-type Ca2+ channel alpha 1 subunit|voltage-dependent L-type calcium channel subunit alpha-1C|voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*
Swissprots	Q13927 Q13936 Q13928 Q13925 Q13929 Q13920 Q99025 Q14743 Q13919 Q99241 Q4VMI8 Q13932 Q8N6C0 Q13922 E9PDJ0 Q13923 Q4VMI7 Q13926 Q99875 Q13930 Q6PKM7 Q15877 Q13917 Q4VMI9 Q13933 Q13918 B2RUT3 Q13924 Q13921 Q14744
Accessions	AAA02500 AAA17030 AAA58409 AAA74590 ABA29771 ABA29772 ABA29773 ABA29774 EAW88895 EAW88896 EAW88897 EAW88898 EAW88899 EAW88900 EAW88901 EAW88902 EAW88903 EAW88904 EAW88905 EAW88906 EAW88907 EAW88908 EAW88909 EAW88910 Q13936 AB209016 BAD92253 AF070589 AAC28649 AF465484 AAM70049 AJ224873 CAA12174 AJ536834 CAD61168 AJ537510 CAD61169 AK092125 AK302698 BAH13781 AK308652 AK309111 AY129012 AAM98755 AY562395 AAT67986 AY562396 AAT67987 AY604867 AAT02226 AY830711 AAX37354 AY830712 AAX37355 AY830713 AAX37356 BC093695 AAH93695 BC146846 AAI46847 L29529 AAA51899 L29534 AAA51900 L29536 AAA51901 M57971 AAA62832 M57972 AAB59461 Z26294 CAA81218 Z26295 CAA81219 Z34809 CAA84340 Z34810 CAA84341 Z34811 CAA84342 Z34812 CAA84343 Z34813 CAA84344 Z34814 CAA84345 Z34815 CAA84346 Z34816 CAA84347 Z34817 CAA84348 Z34818 CAA84349 Z34819 CAA84350 Z34820 CAA84351 Z34821 CAA84352 Z34822 CAA84353 Z74996 CAA99284 XM_006719017 XP_006719080 XM_011521017 XP_011519319 XM_011521018 XP_011519320 XM_011521019 XP_011519321 XM_011521020 XP_011519322 XM_011521021 XP_011519323 XM_011521022 XP_011519324 XM_011521023 XP_011519325 NM_000719 NP_000710 NM_001129827 NP_001123299 NM_001129829 NP_001123301 NM_001129830 NP_001123302 NM_001129831 NP_001123303 NM_001129832 NP_001123304 NM_001129833 NP_001123305 NM_001129834 NP_001123306 NM_001129835 NP_001123307 NM_001129836 NP_001123308 NM_001129837 NP_001123309 NM_001129838 NP_001123310 NM_001129839 NP_001123311 NM_001129840 NP_001123312 NM_001129841 NP_001123313 NM_001129842 NP_001123314 NM_001129843 NP_001123315 NM_001129844 NP_001123316 NM_001129846 NP_001123318 NM_001167623 NP_001161095 NM_001167624 NP_001161096 NM_001167625 NP_001161097 NM_199460 NP_955630
Function	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function
Subcellular Location	Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}. Note=The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane. {ECO:0000250}.
Tissue Specificity	Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle. {ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:17071743, ECO:0000269|PubMed:8392192}.
Top Pathways	MAPK signaling pathway, Circadian entrainment, Calcium signaling pathway, Adrenergic signaling in cardiomyocytes, GnRH signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse CACNA1C / Cav1.2 ELISA Kit (Sandwich ELISA) - LS-F8773 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.115 ng/ml Range 0.313-20 ng/ml

Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), Human, ELISA Kit - E01V0057 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Voltage-gated calcium channel, ELISA Kit - MBS741641 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-gated calcium channel, ELISA Kit - MBS721419 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Voltage-gated calcium channel, ELISA Kit - MBS742421 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-gated calcium channel, ELISA Kit - MBS743198 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-gated calcium channel, ELISA Kit - MBS744000 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-gated calcium channel, ELISA Kit - MBS727370 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-gated calcium channel, ELISA Kit - MBS737400 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Voltage-gated calcium channel, ELISA Kit - MBS740237 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Voltage-gated calcium channel, ELISA Kit - MBS732820 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-gated calcium channel, ELISA Kit - MBS723938 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-gated calcium channel, ELISA Kit - MBS738533 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Voltage dependent L type calcium channel subunit Alpha 1C (CACNA1C), ELISA Kit - MBS7208086 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage gated calcium channel, ELISA Kit - MBS720076 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,850.00, $5,340.00 Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive)

Voltage-dependent L-type calcium channel subunit Alpha 1C (CACNA1C), ELISA Kit - MBS7234326 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), ELISA Kit - MBS7243524 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), ELISA Kit - MBS7244305 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), ELISA Kit - MBS7245373 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), ELISA Kit - MBS7233352 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), ELISA Kit - MBS7226445 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), ELISA Kit - MBS7206766 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), ELISA Kit - MBS7247512 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), ELISA Kit - MBS7203230 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), ELISA Kit - MBS7225817 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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