| Gene Symbol |
Sept2
|
| Entrez Gene |
117515
|
| Alt Symbol |
Nedd5, Vesp11
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
septin 2
|
| Other Description |
septin-2|vascular endothelial cell specific protein 11
|
| Swissprots |
Q91Y81
|
| Accessions |
EDL91920 EDL91921 EDL91922 EDL91923 EDL91924 EDL91925 EDL91926 EDL91927 EDL91928 Q91Y81 AB027561 BAB47151 BC081745 AAH81745 FQ212097 FQ228229 XM_006245511 XP_006245573 XM_006245512 XP_006245574 XM_006245513 XP_006245575 XM_006245514 XP_006245576 NM_057148 NP_476489
|
| Function |
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, cilium membrane {ECO:0000250}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes (By similarity). {ECO:0000250}.
|
| Top Pathways |
Bacterial invasion of epithelial cells
|