| Gene Symbol |
CCL5
|
| Entrez Gene |
493689
|
| Alt Symbol |
RANTES
|
| Species |
Cat
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-C motif) ligand 5
|
| Other Description |
C-C motif chemokine 5|T-cell-specific protein RANTES|small inducible cytokine A5|small-inducible cytokine A5
|
| Swissprots |
Q8SQ40
|
| Accessions |
Q8SQ40 AB003368 BAH84774 AB083479 BAB88940 NM_001009827 NP_001009827
|
| Function |
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. {ECO:0000250|UniProtKB:P13501}.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
TNF signaling pathway, Cytokine-cytokine receptor interaction, Herpes simplex infection, Influenza A, Rheumatoid arthritis
|
