| Gene Symbol |
Ppp1cc
|
| Entrez Gene |
24669
|
| Alt Symbol |
PP-1G, Ppp1cc1
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 1, catalytic subunit, gamma isozyme
|
| Other Description |
protein phosphatase 1C catalytic subunit|protein serine-threonine phosphatase catalytic subunit PP-1b|serine/threonine-protein phosphatase PP1-gamma catalytic subunit
|
| Swissprots |
O09186 P37139 Q64679 P63088 O09189
|
| Accessions |
EDM13704 EDM13706 P63088 BC078825 AAH78825 CB740494 D90165 BAA14196 D90166 BAA14197 DV727747 FM102812 FM122849 FN803249 FQ211612 FQ228186 FQ232892 M58435 AAA41906 XM_008769212 XP_008767434 NM_001270983 NP_001257912 NM_022498 NP_071943
|
| Function |
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. {ECO:0000250|UniProtKB:P36873}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cleavage furrow {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Nucleus speckle {ECO:0000250}. Midbody {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles. Shows a dynamic targeting to specific sites throughout the cell cycle. Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis. Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase. Also accumulates at the cleavage furrow and midbody by telophase. Colocalizes with SPZ1 in the nucleus. Colocalizes with URI1 at mitochondrion (By similarity). {ECO:0000250}.
|
| Top Pathways |
Amphetamine addiction, cGMP-PKG signaling pathway, Oxytocin signaling pathway, Inflammatory mediator regulation of TRP channels, cAMP signaling pathway
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