| Gene Symbol |
SH3BP2
|
| Entrez Gene |
6452
|
| Alt Symbol |
3BP-2, 3BP2, CRBM, CRPM, RES4-23
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SH3-domain binding protein 2
|
| Other Description |
Abl-SH3 binding protein 2|SH3 domain-binding protein 2|TNFAIP3 interacting protein 2
|
| Swissprots |
D3DVR0 B4DT04 A6NNC2 D6R919 P78315 P78314 B2R5R6 O15373 O00500
|
| Accessions |
CAH05621 EAW82506 EAW82507 EAW82508 EAW82509 EAW82510 EAW82511 EAW82512 EAW82513 P78314 AB000462 BAA19119 AB000463 BAA19120 AF000936 AAB59973 AK124073 BAC85767 AK126537 BAC86582 AK225497 AK299996 BAG61816 AK304752 BAH14252 AK307106 AK312286 BAG35213 BC022996 AAH22996 DC391267 U56386 AAB72034 XM_005247998 XP_005248055 XM_005247999 XP_005248056 XM_011513547 XP_011511849 XM_011513548 XP_011511850 XM_011513549 XP_011511851 XM_011513550 XP_011511852 XM_011513551 XP_011511853 XM_011513552 XP_011511854 XM_011513553 XP_011511855 XM_011513554 XP_011511856 XM_011513555 XP_011511857 XM_011513556 XP_011511858 XR_924990 NM_001122681 NP_001116153 NM_001145855 NP_001139327 NM_001145856 NP_001139328 NM_003023 NP_003014
|
| Function |
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
|
| Tissue Specificity |
Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:9734812}.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity
|
![Western Blot: SH3BP2 Overexpression Lysate (Adult Normal) [NBP2-09407] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SH3BP2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6091_SH3BP2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09407-img0001.jpg)
![Western Blot: SH3BP2 Overexpression Lysate (Adult Normal) [NBL1-15927] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SH3BP2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/19454_SH3BP2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-15927-img0002.jpg)