| Gene Symbol |
UBOX5
|
| Entrez Gene |
22888
|
| Alt Symbol |
RNF37, UBCE7IP5, UIP5, hUIP5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
U-box domain containing 5
|
| Other Description |
RING finger protein 37|U-box domain-containing protein 5|ubcM4-interacting protein 5|ubiquitin conjugating enzyme 7 interacting protein 5|ubiquitin-conjugating enzyme 7-interacting protein 5
|
| Swissprots |
Q86X87 Q6IAR5 Q9H4J2 O94941
|
| Accessions |
EAX10549 EAX10550 EAX10551 O94941 AB020667 BAA74883 AK022444 BAG51073 AK222570 BAD96290 AK222876 BAD96596 BC000515 AAH00515 BC046122 AAH46122 BC064544 BM992259 BX475562 CR457089 CAG33370 DA101925 DQ892015 ABM82941 DQ895205 ABM86131 NM_001267584 NP_001254513 NM_014948 NP_055763 NM_199415 NP_955447
|
| Function |
May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. {ECO:0000250|UniProtKB:Q925F4}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11274149, ECO:0000269|PubMed:11435423}. Note=Enriched in nuclear bodies. {ECO:0000269|PubMed:11274149}.
|
| Tissue Specificity |
Expressed in liver, heart, brain, kidney and testis. {ECO:0000269|PubMed:11435423}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|
![Western Blot: UBOX5 Overexpression Lysate (Adult Normal) [NBL1-17560] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for UBOX5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8923_UBOX5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17560-img0002.jpg)