| Gene Symbol | Gls |
|---|---|
| Entrez Gene | 24398 |
| Alt Symbol | Glut, RATGLUT |
| Species | Rat |
| Gene Type | protein-coding |
| Description | glutaminase |
| Other Description | K-glutaminase|L-glutamine amidohydrolase|glutaminase kidney isoform, mitochondrial |
| Swissprots | P13264 Q8R421 |
| Accessions | EDL99093 EDL99094 P13264 AY083459 AAM00020 CB776615 FQ216488 M22586 AAA41234 M65150 AAA41247 XM_008767075 XP_008765297 NM_001109968 NP_001103438 NM_012569 NP_036701 |
| Function | Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. |
| Subcellular Location | Isoform 1: Cytoplasm, cytosol {ECO:0000250}. |
| Tissue Specificity | Kidney, brain, and intestine. |
| Top Pathways | Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation |