Gene Symbol | Gls |
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Entrez Gene | 24398 |
Alt Symbol | Glut, RATGLUT |
Species | Rat |
Gene Type | protein-coding |
Description | glutaminase |
Other Description | K-glutaminase|L-glutamine amidohydrolase|glutaminase kidney isoform, mitochondrial |
Swissprots | P13264 Q8R421 |
Accessions | EDL99093 EDL99094 P13264 AY083459 AAM00020 CB776615 FQ216488 M22586 AAA41234 M65150 AAA41247 XM_008767075 XP_008765297 NM_001109968 NP_001103438 NM_012569 NP_036701 |
Function | Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. |
Subcellular Location | Isoform 1: Cytoplasm, cytosol {ECO:0000250}. |
Tissue Specificity | Kidney, brain, and intestine. |
Top Pathways | Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation |
CompoZr® Knockout ZFN Kit - CKOZFN54494 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND54494 from Sigma-Aldrich
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GLS siRNA (Rat) - CRR0120 from Cohesion Biosciences
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GLS - MBS8202701 from MyBioSource
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shRNA set against Rat GLS (NM_012569.2) - SHH302046 from Creative biogene
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shRNA set against Rat Gls(NM_012569.2) - SHH087959 from Creative biogene
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GLS shRNA Plasmid (Rat) - CHR0120 from Cohesion Biosciences
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GLS miRNA 3'UTR clone - MiUTR1R-02143 from Creative biogene
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