Gene Symbol | TGFBRAP1 |
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Entrez Gene | 9392 |
Alt Symbol | TRAP-1, TRAP1 |
Species | Human |
Gene Type | protein-coding |
Description | transforming growth factor, beta receptor associated protein 1 |
Other Description | TGF beta receptor associated protein -1|TGF-beta receptor-associated protein 1|transforming growth factor-beta receptor-associated protein 1 |
Swissprots | Q8WUH2 A8K5R7 O60466 D3DVJ8 |
Accessions | AAY15010 CAT02179 EAX01764 EAX01765 Q8WUH2 AF022795 AAC16903 AK021697 BAG51041 AK291382 BAF84071 BC011136 AAH11136 BC019841 BC020548 AAH20548 CT002669 DB150781 DQ891559 ABM82485 EU176617 ABW03418 HG494419 XM_011512193 XP_011510495 NM_001142621 NP_001136093 NM_004257 NP_004248 |
Function | Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. {ECO:0000269|PubMed:11278302, ECO:0000269|PubMed:9545258}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11278302}. Note=Colocalizes with TGF-beta receptors in the absence of signaling. |
TRAP-1 CRISPR/Cas9 KO Plasmid (h) - sc-402963 from Santa Cruz Biotechnology
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TRAP-1 HDR Plasmid (h) - sc-402963-HDR from Santa Cruz Biotechnology
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TRAP-1 Double Nickase Plasmid (h) - sc-402963-NIC from Santa Cruz Biotechnology
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TRAP-1 Double Nickase Plasmid (h2) - sc-402963-NIC-2 from Santa Cruz Biotechnology
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TRAP-1 CRISPR Activation Plasmid (h) - sc-402963-ACT from Santa Cruz Biotechnology
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TRAP-1 CRISPR Activation Plasmid (h2) - sc-402963-ACT-2 from Santa Cruz Biotechnology
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TRAP-1 Lentiviral Activation Particles (h) - sc-402963-LAC from Santa Cruz Biotechnology
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TRAP-1 Lentiviral Activation Particles (h2) - sc-402963-LAC-2 from Santa Cruz Biotechnology
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TRAP-1 siRNA (h) - sc-36720 from Santa Cruz Biotechnology
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TRAP-1 shRNA Plasmid (h) - sc-36720-SH from Santa Cruz Biotechnology
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TRAP-1 shRNA (h) Lentiviral Particles - sc-36720-V from Santa Cruz Biotechnology
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TGFBRAP1 RNAi - H00009392-R02 from Novus Biologicals
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MISSION® esiRNA - EHU011341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21277 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21277 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02076 from Sigma-Aldrich
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TGFBRAP1 siRNA (Human) - CRH6225 from Cohesion Biosciences
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TGFBRAP1 - MBS8204427 from MyBioSource
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shRNA set against Human TGFBRAP1 (NM_004257.4) - SHH426468 from Creative biogene
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Human TGFBRAP1 siRNA - orb266727 from Biorbyt
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TGFBRAP1 shRNA Plasmid (Human) - CHH6225 from Cohesion Biosciences
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TGFBRAP1 miRNA 3'UTR clone - MiUTR3H-08304 from Creative biogene
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TGFBRAP1 miRNA 3'UTR clone - MiUTR3H-08305 from Creative biogene
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