| Gene Symbol | Meis2 |
|---|---|
| Entrez Gene | 17536 |
| Alt Symbol | A430109D20Rik, Mrg1, Stra10 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | Meis homeobox 2 |
| Other Description | Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2|Meis2 homeobox|homeobox protein Meis2|meis1-related protein 1|myeloid ecotropic viral integration site-related gene 1 |
| Swissprots | P97403 O35677 P97367 P97404 O35676 |
| Accessions | EDL27882 EDL27883 P97367 AJ000504 CAA04138 AJ000505 CAA04139 AJ000506 CAA04140 AJ000507 CAA04141 AK040611 AK043601 AK045126 AK080665 AK135756 AK139902 AK146633 BAE27320 AK158513 BAE34540 AK158839 BAE34690 AK187728 AK217632 AK218099 BC017375 AAH17375 BQ443762 HG978595 KM974607 KM974612 KM974644 AIY68055 KP101221 U57343 AAC52948 U68383 AAB19193 U68384 AAB19194 XM_006498862 XP_006498925 XM_006498863 XP_006498926 XM_006498864 XP_006498927 XM_006498865 XP_006498928 XM_006498866 XP_006498929 XM_006498867 XP_006498930 XM_006498868 XP_006498931 XM_006498869 XP_006498932 XM_006498870 XP_006498933 XM_006498871 XP_006498934 XM_011239336 XP_011237638 XM_011239337 XP_011237639 XM_011239338 XP_011237640 XM_011239339 XP_011237641 NM_001136072 NP_001129544 NM_001159567 NP_001153039 NM_001159568 NP_001153040 NM_001159569 NP_001153041 NM_001159570 NP_001153042 NM_010825 NP_034955 |
| Function | Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoforms 3/Meis2B and 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3' |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000269|PubMed:9710595}. |
| Tissue Specificity | Displays spatially restricted expression patterns in the developing nervous system, limbs, face, and in various viscera. In adult, it is mainly expressed in the brain and female genital tract, with a different distribution of the alternative splice forms in these organs. Lower expression in lung and only basal level in heart, liver, kidney, spleen, and testis. |
Meis2 CRISPR/Cas9 KO Plasmid (m) - sc-421710 from Santa Cruz Biotechnology
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Meis2 HDR Plasmid (m) - sc-421710-HDR from Santa Cruz Biotechnology
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Meis2 Double Nickase Plasmid (m) - sc-421710-NIC from Santa Cruz Biotechnology
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Meis2 Double Nickase Plasmid (m2) - sc-421710-NIC-2 from Santa Cruz Biotechnology
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Meis2 CRISPR Activation Plasmid (m) - sc-421710-ACT from Santa Cruz Biotechnology
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Meis2 CRISPR Activation Plasmid (m2) - sc-421710-ACT-2 from Santa Cruz Biotechnology
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Meis2 Lentiviral Activation Particles (m) - sc-421710-LAC from Santa Cruz Biotechnology
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Meis2 Lentiviral Activation Particles (m2) - sc-421710-LAC-2 from Santa Cruz Biotechnology
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Meis2 siRNA (m) - sc-38795 from Santa Cruz Biotechnology
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Meis2 shRNA Plasmid (m) - sc-38795-SH from Santa Cruz Biotechnology
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Meis2 shRNA (m) Lentiviral Particles - sc-38795-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU047711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN35457 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35457 from Sigma-Aldrich
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MEIS2 siRNA (Mouse) - CRM2593 from Cohesion Biosciences
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shRNA set against Mouse MEIS2 (NM_010825.3) - SHH340347 from Creative biogene
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MEIS2 shRNA Plasmid (Mouse) - CHM2593 from Cohesion Biosciences
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