Gene Symbol | PPHLN1 |
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Entrez Gene | 51535 |
Alt Symbol | HSPC206, HSPC232 |
Species | Human |
Gene Type | protein-coding |
Description | periphilin 1 |
Other Description | gastric cancer antigen Ga50|periphilin-1 |
Swissprots | Q9NXL4 Q9P0P6 Q8NEY8 Q8TB09 Q8IXN3 E9PAX8 Q96NB9 Q9P0R9 Q86YT2 |
Accessions | EAW57845 EAW57846 EAW57847 EAW57848 EAW57849 EAW57850 EAW57851 EAW57852 EAW57853 Q8NEY8 AF151040 AAF36126 AF151066 AAF36152 AK000186 BAA90996 AK055690 BAB70985 AK056622 AK124921 AK129910 AK299951 BAH13181 AK303612 BAH13997 AK303680 BAH14015 AK308022 AY039238 AAK68657 AY157850 AAO16497 BC015322 BC025306 AAH25306 BC039832 AAH39832 BC040449 BM995486 BQ081957 BX647697 CA444170 CF242917 DC424443 HQ448511 ADQ32990 R89350 XM_005268962 XP_005269019 XM_005268965 XP_005269022 XM_011538457 XP_011536759 XM_011538458 XP_011536760 XM_011538459 XP_011536761 XM_011538460 XP_011536762 XM_011538461 XP_011536763 XM_011538462 XP_011536764 XM_011538463 XP_011536765 XM_011538464 XP_011536766 XM_011538465 XP_011536767 XM_011538466 XP_011536768 XM_011538467 XP_011536769 XM_011538468 XP_011536770 XM_011538469 XP_011536771 XM_011538470 XP_011536772 XM_011538471 XP_011536773 XM_011538472 XP_011536774 XM_011538473 XP_011536775 XM_011538474 XP_011536776 XM_011538475 XP_011536777 NM_001143787 NP_001137259 NM_001143788 NP_001137260 NM_001143789 NP_001137261 NM_016488 NP_057572 NM_201438 NP_958846 NM_201439 NP_958847 NM_201440 NP_958848 NM_201515 NP_958923 |
Function | Involved in epithelial differentiation and contributes to epidermal integrity and barrier formation. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12853457}. Cytoplasm {ECO:0000269|PubMed:12853457}. Note=In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:12853457}. |
periphilin 1 CRISPR/Cas9 KO Plasmid (h) - sc-409441 from Santa Cruz Biotechnology
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periphilin 1 HDR Plasmid (h) - sc-409441-HDR from Santa Cruz Biotechnology
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periphilin 1 Double Nickase Plasmid (h) - sc-409441-NIC from Santa Cruz Biotechnology
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periphilin 1 Double Nickase Plasmid (h2) - sc-409441-NIC-2 from Santa Cruz Biotechnology
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periphilin 1 CRISPR Activation Plasmid (h) - sc-409441-ACT from Santa Cruz Biotechnology
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periphilin 1 CRISPR Activation Plasmid (h2) - sc-409441-ACT-2 from Santa Cruz Biotechnology
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periphilin 1 Lentiviral Activation Particles (h) - sc-409441-LAC from Santa Cruz Biotechnology
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periphilin 1 Lentiviral Activation Particles (h2) - sc-409441-LAC-2 from Santa Cruz Biotechnology
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periphilin 1 siRNA (h) - sc-95892 from Santa Cruz Biotechnology
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periphilin 1 shRNA Plasmid (h) - sc-95892-SH from Santa Cruz Biotechnology
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periphilin 1 shRNA (h) Lentiviral Particles - sc-95892-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU081961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17218 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17218 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10825 from Sigma-Aldrich
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PPHLN1 siRNA (Human) - CRH9818 from Cohesion Biosciences
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shRNA set against Human PPHLN1 (NM_201515.1) - SHH380544 from Creative biogene
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shRNA set against Human PPHLN1(NM_201515.1) - SHR131460 from Creative biogene
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shRNA set against Human PPHLN1(NM_201440.1) - SHR131620 from Creative biogene
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shRNA set against Human PPHLN1(NM_201438.1) - SHR131656 from Creative biogene
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shRNA set against Human PPHLN1(NM_201515.1) - SHR131688 from Creative biogene
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shRNA set against Human PPHLN1(NM_201439.1) - SHR131754 from Creative biogene
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PPHLN1 shRNA Plasmid (Human) - CHH9818 from Cohesion Biosciences
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PPHLN1 miRNA 3'UTR clone - MiUTR1H-08145 from Creative biogene
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PPHLN1 miRNA 3'UTR clone - MiUTR1H-08146 from Creative biogene
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