| Gene Symbol |
Lyve1
|
| Entrez Gene |
114332
|
| Alt Symbol |
1200012G08Rik, Crsbp-1, Lyve-1, Xlkd1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
lymphatic vessel endothelial hyaluronan receptor 1
|
| Other Description |
cell surface retention sequence binding protein-1|cell surface retention sequence-binding protein 1|extra cellular link domain-containing 1|extracellular link domain-containing protein 1|lymphatic vessel endothelial HA receptor-1|lymphatic vessel endothelial HA recptor-1|lymphatic vessel endothelial hyaluronic acid receptor 1
|
| Swissprots |
Q99NE4 Q3TUC1 Q8BHC0
|
| Accessions |
EDL16997 Q8BHC0 AJ311501 CAC33082 AK004182 AK004726 BAC25094 AK160857 BAE36050 BC038653 AAH38653 BC038892 AAH38892 NM_053247 NP_444477
|
| Function |
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. {ECO:0000269|PubMed:10187853}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:10187853}; Single-pass type I membrane protein {ECO:0000269|PubMed:10187853}. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand- dependent internalization and recycling at the cell surface.
|