| Gene Symbol | BCL3 |
|---|---|
| Entrez Gene | 602 |
| Alt Symbol | BCL4, D19S37 |
| Species | Human |
| Gene Type | protein-coding |
| Description | B-cell CLL/lymphoma 3 |
| Other Description | B-cell leukemia/lymphoma 3|B-cell lymphoma 3 protein|B-cell lymphoma 3-encoded protein|BCL-3|chronic lymphatic leukemia protein|proto-oncogene BCL3 |
| Swissprots | P20749 |
| Accessions | AAA51816 EAW57291 P20749 AK296180 BAH12275 AK309453 BC064993 AAH64993 BU501187 M31732 AAA51815 XM_011527197 XP_011525499 XM_011527198 XP_011525500 XM_011527199 XP_011525501 XM_011527200 XP_011525502 NM_005178 NP_005169 |
| Function | Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Ubiquitination via 'Lys- 63'-linked ubiquitin chains is required for nuclear accumulation. {ECO:0000250}. |
| Top Pathways | TNF signaling pathway |