Gene Symbol | BCL3 |
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Entrez Gene | 602 |
Alt Symbol | BCL4, D19S37 |
Species | Human |
Gene Type | protein-coding |
Description | B-cell CLL/lymphoma 3 |
Other Description | B-cell leukemia/lymphoma 3|B-cell lymphoma 3 protein|B-cell lymphoma 3-encoded protein|BCL-3|chronic lymphatic leukemia protein|proto-oncogene BCL3 |
Swissprots | P20749 |
Accessions | AAA51816 EAW57291 P20749 AK296180 BAH12275 AK309453 BC064993 AAH64993 BU501187 M31732 AAA51815 XM_011527197 XP_011525499 XM_011527198 XP_011525500 XM_011527199 XP_011525501 XM_011527200 XP_011525502 NM_005178 NP_005169 |
Function | Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Ubiquitination via 'Lys- 63'-linked ubiquitin chains is required for nuclear accumulation. {ECO:0000250}. |
Top Pathways | TNF signaling pathway |
Bcl-3 CRISPR/Cas9 KO Plasmid (h) - sc-400740 from Santa Cruz Biotechnology
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Bcl-3 HDR Plasmid (h) - sc-400740-HDR from Santa Cruz Biotechnology
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Bcl-3 Double Nickase Plasmid (h) - sc-400740-NIC from Santa Cruz Biotechnology
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Bcl-3 Double Nickase Plasmid (h2) - sc-400740-NIC-2 from Santa Cruz Biotechnology
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Bcl-3 CRISPR Activation Plasmid (h) - sc-400740-ACT from Santa Cruz Biotechnology
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Bcl-3 CRISPR Activation Plasmid (h2) - sc-400740-ACT-2 from Santa Cruz Biotechnology
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Bcl-3 Lentiviral Activation Particles (h) - sc-400740-LAC from Santa Cruz Biotechnology
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Bcl-3 Lentiviral Activation Particles (h2) - sc-400740-LAC-2 from Santa Cruz Biotechnology
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Bcl-3 siRNA (h) - sc-29789 from Santa Cruz Biotechnology
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Bcl-3 shRNA Plasmid (h) - sc-29789-SH from Santa Cruz Biotechnology
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Bcl-3 shRNA (h) Lentiviral Particles - sc-29789-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU054231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3916 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3916 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04156 from Sigma-Aldrich
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BCL3 siRNA (Human) - CRH0413 from Cohesion Biosciences
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BCL3 - MBS8208638 from MyBioSource
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shRNA set against Human BCL3 (NM_005178.4) - SHH246006 from Creative biogene
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shRNA set against Human BCL3(NM_005178.4) - SHG097693 from Creative biogene
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Human BCL3 siRNA - orb260915 from Biorbyt
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BCL3 shRNA Plasmid (Human) - CHH0413 from Cohesion Biosciences
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BCL3 miRNA 3'UTR clone - MiUTR1H-00848 from Creative biogene
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