| Gene Symbol | B3GNT3 |
|---|---|
| Entrez Gene | 10331 |
| Alt Symbol | B3GAL-T8, B3GN-T3, B3GNT-3, HP10328, TMEM3, beta3Gn-T3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 |
| Other Description | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3|UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8|beta-1,3-GalTase 8|beta-1,3-Gn-T3|beta-1,3-N-acetylglucosaminyltransferase bGnT-3|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase|beta-3-Gx-T8|beta3GalT8|core 1 extending beta-1,3-N-acetylglucosaminyltransferase|core1-beta3GlcNAcT|putative type II membrane protein|transmembrane protein 3 |
| Swissprots | Q9C0J2 Q8WWR6 Q6NWU9 Q9Y2A9 B2RAS4 Q6NXU9 |
| Accessions | EAW84631 Q9Y2A9 AB015630 BAA76497 AB049585 BAB21531 AF293973 AAK00849 AJ130847 CAC45044 AJ278961 CAC82374 AK075434 AK075466 BAG52147 AK225421 AK225478 AK314323 BAG36971 AW848963 AY358955 AAQ89314 BC066876 AAH66876 BC067423 AAH67423 DA385410 DB104034 HQ447547 ADQ32033 XM_011527626 XP_011525928 XM_011527627 XP_011525929 NM_014256 NP_055071 |
| Function | Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides (PubMed:11042166). Also acts as a core1-1,3-N- acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6- sulfo sialyl Lewis x on extended core1 O-glycans (PubMed:11439191). {ECO:0000269|PubMed:11042166, ECO:0000269|PubMed:11439191}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed in colon, jejunum, stomach, esophagus, placenta and trachea. {ECO:0000269|PubMed:11042166}. |
| Top Pathways | Glycosphingolipid biosynthesis - lacto and neolacto series |