Gene Symbol | Lax1 |
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Entrez Gene | 240754 |
Alt Symbol | A530029E09, E430019B13Rik |
Species | Mouse |
Gene Type | protein-coding |
Description | lymphocyte transmembrane adaptor 1 |
Other Description | linker for activation of X cells|lymphocyte transmembrane adapter 1|membrane-associated adapter protein LAX |
Swissprots | Q8BHB3 Q8CGV1 Q8BS18 |
Accessions | EDL39637 EDL39638 Q8BHB3 AK040834 BAC30715 AK088503 BAC40394 AY090785 AAM09819 BC042765 AAH42765 XM_006529557 XP_006529620 NM_001159649 NP_001153121 NM_172842 NP_766430 |
Function | Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells. {ECO:0000269|PubMed:15843560}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed in T-cells and B-cells. {ECO:0000269|PubMed:15843560}. |
LAX1 CRISPR/Cas9 KO Plasmid (m) - sc-433788 from Santa Cruz Biotechnology
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LAX1 HDR Plasmid (m) - sc-433788-HDR from Santa Cruz Biotechnology
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LAX1 Double Nickase Plasmid (m) - sc-433788-NIC from Santa Cruz Biotechnology
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LAX1 Double Nickase Plasmid (m2) - sc-433788-NIC-2 from Santa Cruz Biotechnology
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LAX1 CRISPR Activation Plasmid (m) - sc-433788-ACT from Santa Cruz Biotechnology
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LAX1 CRISPR Activation Plasmid (m2) - sc-433788-ACT-2 from Santa Cruz Biotechnology
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LAX1 Lentiviral Activation Particles (m) - sc-433788-LAC from Santa Cruz Biotechnology
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LAX1 Lentiviral Activation Particles (m2) - sc-433788-LAC-2 from Santa Cruz Biotechnology
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LAX1 siRNA (m) - sc-146658 from Santa Cruz Biotechnology
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LAX1 shRNA Plasmid (m) - sc-146658-SH from Santa Cruz Biotechnology
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LAX1 shRNA (m) Lentiviral Particles - sc-146658-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU053701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN34639 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND34639 from Sigma-Aldrich
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LAX1 siRNA (Mouse) - CRN3499 from Cohesion Biosciences
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shRNA set against Mouse LAX1 (NM_172842.3) - SHH328707 from Creative biogene
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Mouse LAX1 siRNA - orb292974 from Biorbyt
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LAX1 shRNA Plasmid (Mouse) - CHN3499 from Cohesion Biosciences
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