| Gene Symbol | Ggt1 |
|---|---|
| Entrez Gene | 14598 |
| Alt Symbol | CD224, GGT, GGT 1, GGT-1, Ggtp, dwg |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | gamma-glutamyltransferase 1 |
| Other Description | gamma-glutamyltranspeptidase 1|glutathione hydrolase 1|leukotriene-C4 hydrolase |
| Swissprots | Q60928 |
| Accessions | EDL31902 EDL31903 EDL31904 EDL31905 EDL31906 EDL31907 EDL31908 EDL31909 Q60928 AK079235 BC012969 AAH12969 BU756502 CT010196 CAJ18404 L17331 L17332 L17333 L17334 L17335 L17336 S78533 U30509 AAA97395 XM_006513230 XP_006513293 XM_006513231 XP_006513294 XM_006513232 XP_006513295 XM_011243371 XP_011241673 NM_001305992 NP_001292921 NM_008116 NP_032142 |
| Function | Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Indirectly regulates multiple aspects of skeletal biology. {ECO:0000269|PubMed:12810527}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Top Pathways | Taurine and hypotaurine metabolism, Glutathione metabolism, Arachidonic acid metabolism, Cyanoamino acid metabolism |