| Gene Symbol |
Wwp2
|
| Entrez Gene |
66894
|
| Alt Symbol |
1300010O06Rik, AA690238, AIP2, AW554328
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
WW domain containing E3 ubiquitin protein ligase 2
|
| Other Description |
NEDD4-like E3 ubiquitin-protein ligase WWP2|WW domain-containing protein 2|WW domain-containing protein 4
|
| Swissprots |
Q9DBH0 Q8BTG4 Q923F6
|
| Accessions |
EDL11409 Q9DBH0 AK004087 AK004452 BAB23311 AK004962 BAB23702 AK053749 AK076077 AK088936 BAC40661 AK090392 BAC41195 AK141281 AK146306 BAE27062 AK151548 AK159248 BAE34929 AK177111 AK181554 AK183794 AK186426 AK187158 AK192573 AK195003 AK199742 AK207574 AK209311 AK210078 AK217598 BC004712 AAH04712 BC018496 BC021524 BC039921 AAH39921 BC048184 AAH48184 HQ896246 ADZ74077 JN712751 AFK29260 XM_006531299 XP_006531362 XM_006531301 XP_006531364 XM_011248488 XP_011246790 NM_025830 NP_080106
|
| Function |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; regulates POU5F1 protein level during differentiation of embryonal carcinoma cells (ECCs) but not in undifferentiated ECCs and embryonic stem cells (ESCs). Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. {ECO:0000269|PubMed:17526739, ECO:0000269|PubMed:18776082, ECO:0000269|PubMed:19651900, ECO:0000269|PubMed:19997087}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|