| Gene Symbol |
CD24
|
| Entrez Gene |
100133941
|
| Alt Symbol |
CD24A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CD24 molecule
|
| Other Description |
CD24 antigen (small cell lung carcinoma cluster 4 antigen)|signal transducer CD24
|
| Swissprots |
P25063 Q53XS0 Q16257
|
| Accessions |
ACI46150 AFJ05147 CDM22271 P25063 AK026603 AK125531 AL535013 AU125939 BC064619 AAH64619 BG260536 BG755979 BT007404 AAP36068 BU580553 D87667 DA253943 DA378105 DA518957 DA745135 DA753855 DQ530230 DQ530231 DQ530232 DQ530233 DQ530234 DQ890636 ABM92253 DQ893812 ABM84738 L33930 AAB58807 M58664 AAA35665 X69397 CAA49195 XM_011535375 XP_011533677 NM_001291737 NP_001278666 NM_001291738 NP_001278667 NM_001291739 NP_001278668 NM_013230 NP_037362 NR_117089 NR_117090
|
| Function |
Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. {ECO:0000269|PubMed:11313396}.
|
| Subcellular Location |
Cell membrane; Lipid-anchor, GPI-anchor.
|
| Tissue Specificity |
B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. {ECO:0000269|PubMed:14657362, ECO:0000269|PubMed:8753773}.
|
| Top Pathways |
Hematopoietic cell lineage
|