Gene Symbol | DAZ2 |
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Entrez Gene | 57055 |
Alt Symbol | pDP1678 |
Species | Human |
Gene Type | protein-coding |
Description | deleted in azoospermia 2 |
Other Description | deleted in azoospermia protein 2 |
Swissprots | Q96P41 Q13117 Q9NR91 Q2KHN6 |
Accessions | Q13117 AF248480 AAF91329 AF414184 AAL24502 AK302398 BAH13695 AK302690 BAG63919 BC113006 AAI13007 U21663 AAB02393 NM_001005785 NP_001005785 NM_001005786 NP_001005786 NM_020363 NP_065096 |
Function | RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11058556}. Nucleus {ECO:0000269|PubMed:11058556}. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis. |
Tissue Specificity | Testis specific. {ECO:0000269|PubMed:10936047}. |
DAZ2 CRISPR/Cas9 KO Plasmid (h) - sc-417449 from Santa Cruz Biotechnology
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DAZ2 HDR Plasmid (h) - sc-417449-HDR from Santa Cruz Biotechnology
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DAZ2 Double Nickase Plasmid (h) - sc-417449-NIC from Santa Cruz Biotechnology
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DAZ2 Double Nickase Plasmid (h2) - sc-417449-NIC-2 from Santa Cruz Biotechnology
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DAZ2 CRISPR Activation Plasmid (h) - sc-417449-ACT from Santa Cruz Biotechnology
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DAZ2 CRISPR Activation Plasmid (h2) - sc-417449-ACT-2 from Santa Cruz Biotechnology
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DAZ2 Lentiviral Activation Particles (h) - sc-417449-LAC from Santa Cruz Biotechnology
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DAZ2 Lentiviral Activation Particles (h2) - sc-417449-LAC-2 from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN6937 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6937 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10535 from Sigma-Aldrich
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DAZ2 siRNA (Human) - CRJ1304 from Cohesion Biosciences
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DAZ2 - MBS8208422 from MyBioSource
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shRNA set against Human DAZ2 (NM_001005785.2) - SHH274641 from Creative biogene
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Human DAZ2 siRNA - orb271805 from Biorbyt
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DAZ2 shRNA Plasmid (Human) - CHJ1304 from Cohesion Biosciences
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DAZ2 miRNA 3'UTR clone - MiUTR3H-03052 from Creative biogene
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DAZ2 miRNA 3'UTR clone - MiUTR3H-03053 from Creative biogene
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DAZ2 miRNA 3'UTR clone - MiUTR3H-03054 from Creative biogene
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