| Gene Symbol |
RGP1
|
| Entrez Gene |
9827
|
| Alt Symbol |
KIAA0258
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RGP1 retrograde golgi transport homolog (S. cerevisiae)
|
| Other Description |
RAB6A-GEF complex partner protein 2|retrograde Golgi transport protein RGP1 homolog
|
| Swissprots |
Q5TCV5 Q92546
|
| Accessions |
EAW58343 Q92546 AK289566 BAF82255 BC001725 AAH01725 D87447 BAA13388 DQ600531 HQ447683 ADQ32168 NM_001080496 NP_001073965
|
| Function |
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. {ECO:0000269|PubMed:23091056}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:23091056}. Membrane {ECO:0000269|PubMed:23091056}.
|