Gene Symbol | Oxct2a |
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Entrez Gene | 64059 |
Alt Symbol | Oxct, Oxct2, Scot, Scot-t1 |
Species | Mouse |
Gene Type | protein-coding |
Description | 3-oxoacid CoA transferase 2A |
Other Description | 3-oxoacid CoA-transferase 2A|3-oxoacid-CoA transferase 2A|haploid germ cell specific succinyl CoA transferase|succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial|succinyl-CoA:3-ketoacid-coenzyme A transferase 2A, mitochondrial|succinyl-CoA:3-oxoacid CoA-transferase|testis-specific succinyl CoA:3-oxoacid CoA-transferase 1|testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1 |
Swissprots | B9EHG5 Q9JJN4 |
Accessions | BAC87737 Q9JJN4 AB022180 BAA97654 AB045847 BAB97208 AK077075 BAC36595 BC137887 AAI37888 BC137888 AAI37889 NM_022033 NP_071316 |
Function | Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa. {ECO:0000250}. |
Subcellular Location | Mitochondrion {ECO:0000250}. |
Top Pathways | Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism |
SCOT-t CRISPR/Cas9 KO Plasmid (m) - sc-425667 from Santa Cruz Biotechnology
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SCOT-t HDR Plasmid (m) - sc-425667-HDR from Santa Cruz Biotechnology
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SCOT-t Double Nickase Plasmid (m) - sc-425667-NIC from Santa Cruz Biotechnology
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SCOT-t Double Nickase Plasmid (m2) - sc-425667-NIC-2 from Santa Cruz Biotechnology
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SCOT-t CRISPR Activation Plasmid (m) - sc-425667-ACT from Santa Cruz Biotechnology
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SCOT-t CRISPR Activation Plasmid (m2) - sc-425667-ACT-2 from Santa Cruz Biotechnology
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SCOT-t Lentiviral Activation Particles (m) - sc-425667-LAC from Santa Cruz Biotechnology
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SCOT-t Lentiviral Activation Particles (m2) - sc-425667-LAC-2 from Santa Cruz Biotechnology
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SCOT-t siRNA (m) - sc-153267 from Santa Cruz Biotechnology
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SCOT-t shRNA Plasmid (m) - sc-153267-SH from Santa Cruz Biotechnology
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SCOT-t shRNA (m) Lentiviral Particles - sc-153267-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU198461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN38146 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38146 from Sigma-Aldrich
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OXCT2A siRNA (Mouse) - CRM6276 from Cohesion Biosciences
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shRNA set against Mouse Oxct2a (NM_022033.4) - SHH369324 from Creative biogene
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Mouse OXCT2A siRNA - orb285752 from Biorbyt
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OXCT2A shRNA Plasmid (Mouse) - CHM6276 from Cohesion Biosciences
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