| Gene Symbol |
EIF3K
|
| Entrez Gene |
27335
|
| Alt Symbol |
ARG134, EIF3-p28, EIF3S12, HSPC029, M9, MSTP001, PLAC-24, PLAC24, PRO1474, PTD001
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 3, subunit K
|
| Other Description |
eIF-3 p28|eukaryotic translation initiation factor 3 subunit K|eukaryotic translation initiation factor 3, subunit 12|muscle specific|muscle-specific gene M9 protein
|
| Swissprots |
Q96IQ0 Q9UBQ5 B7ZAM9 A8K0I9 Q9Y6D1
|
| Accessions |
EAW56803 EAW56804 EAW56805 EAW56806 EAW56807 EAW56808 Q9UBQ5 AB019392 BAA76626 AF077051 AAD27784 AF085358 AAD40193 AF109355 AAQ13503 AF315506 AAK01365 AI054400 AK026531 AK289554 BAF82243 AK298635 BAG60810 AK301035 BAG62649 AK316344 BAH14715 AY245432 AAP22070 BC001031 AAH01031 BC007335 AAH07335 BC007559 AAH07559 BF664642 BF965565 BG470776 BG488547 BG943109 BI116511 HQ447243 ADQ31730 JX870647 AGL61413 XM_011526751 XP_011525053 NM_001300992 NP_001287921 NM_001308393 NP_001295322 NM_013234 NP_037366
|
| Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
|
| Subcellular Location |
Nucleus {ECO:0000255|HAMAP-Rule:MF_03010, ECO:0000269|PubMed:15327989}. Cytoplasm {ECO:0000255|HAMAP- Rule:MF_03010, ECO:0000269|PubMed:15327989}.
|
| Tissue Specificity |
Ubiquitous, with the highest levels of expression in brain, testis and kidney. {ECO:0000269|PubMed:14519125}.
|