| Gene Symbol | Fxr1 |
|---|---|
| Entrez Gene | 14359 |
| Alt Symbol | 1110050J02Rik, 9530073J07Rik, AI851072, Fxr1h, Fxr1p |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | fragile X mental retardation gene 1, autosomal homolog |
| Other Description | fragile X mental retardation gene, autosomal homolog|fragile X mental retardation syndrome-related protein 1|fragile X mental retardation-related protein 1|fragile-X-related protein 1|mFxr1p |
| Swissprots | Q9R1E5 Q8VCU4 Q9R1E2 Q9WUA8 Q61584 Q9WUA9 Q9R1E3 Q9WUA7 Q9R1E4 |
| Accessions | AAD30212 AAD30213 AAD30214 AAD30215 AAD30216 AAD30217 EDL35035 EDL35036 EDL35037 EDL35038 EDL35039 Q61584 AA080092 AF124385 AAD30211 AK004220 AK020641 AK049231 BAC33624 AK177421 AK178268 AK180674 AK198118 BC019139 AAH19139 BE634703 CB196254 CF170707 CJ086949 X90875 CAA62383 XM_006535400 XP_006535463 XM_006535401 XP_006535464 XM_006535402 XP_006535465 XM_011249665 XP_011247967 NM_001113188 NP_001106659 NM_001113189 NP_001106660 NM_008053 NP_032079 |
| Function | RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs. {ECO:0000269|PubMed:15128702}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Tissue Specificity | In early embryogenesis, highest expression in somites and central nervous system. Also expressed in spinal cord, surrounding mesenchymal tissue and undifferentiated gonad. In mid- embryogenesis, most prominent in gonad and muscle tissue. Also expressed in liver, retina, telencephalon and mesencephalon. In late embryogenesis, restricted to skeletal muscle and proliferative active layers of brain. After birth, highly expressed in postmeiotic spermatids. Intermediate levels are found in heart, liver and kidney with lower levels in brain and skeletal muscle. Isoform(s) containing the 27 amino acid pocket (residues 564-590) are present in adult heart and muscle. {ECO:0000269|PubMed:10409431, ECO:0000269|PubMed:16000371}. |
| Top Pathways | RNA transport |
FXR1 CRISPR/Cas9 KO Plasmid (m) - sc-420430 from Santa Cruz Biotechnology
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FXR1 HDR Plasmid (m) - sc-420430-HDR from Santa Cruz Biotechnology
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FXR1 Double Nickase Plasmid (m) - sc-420430-NIC from Santa Cruz Biotechnology
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FXR1 Double Nickase Plasmid (m2) - sc-420430-NIC-2 from Santa Cruz Biotechnology
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FXR1 CRISPR Activation Plasmid (m) - sc-420430-ACT from Santa Cruz Biotechnology
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FXR1 CRISPR Activation Plasmid (m2) - sc-420430-ACT-2 from Santa Cruz Biotechnology
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FXR1 Lentiviral Activation Particles (m) - sc-420430-LAC from Santa Cruz Biotechnology
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FXR1 Lentiviral Activation Particles (m2) - sc-420430-LAC-2 from Santa Cruz Biotechnology
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FXR1 siRNA (m) - sc-35424 from Santa Cruz Biotechnology
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FXR1 shRNA Plasmid (m) - sc-35424-SH from Santa Cruz Biotechnology
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FXR1 shRNA (m) Lentiviral Particles - sc-35424-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU200301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN31614 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31614 from Sigma-Aldrich
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FXR1 siRNA (Mouse) - CRM1441 from Cohesion Biosciences
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FXR1 - MBS8211630 from MyBioSource
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shRNA set against Mouse FXR1 (NM_008053.2) - SHH297901 from Creative biogene
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shRNA set against Mouse Fxr1h(NM_008053.2) - SHH071147 from Creative biogene
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FXR1 CRISPR/Cas9 KO Plasmid (m2) - sc-420430-KO-2 from Santa Cruz Biotechnology
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FXR1 HDR Plasmid (m2) - sc-420430-HDR-2 from Santa Cruz Biotechnology
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Mouse FXR1 siRNA - orb280917 from Biorbyt
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FXR1 shRNA Plasmid (Mouse) - CHM1441 from Cohesion Biosciences
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FXR1 miRNA 3'UTR clone - MiUTR1M-04841 from Creative biogene
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