C10orf2

Gene Symbol	C10orf2
Entrez Gene	56652
Alt Symbol	ATXN8, IOSCA, MTDPS7, PEO, PEO1, PEOA3, PRLTS5, SANDO, SCA8, TWINL
Species	Human
Gene Type	protein-coding
Description	chromosome 10 open reading frame 2
Other Description	T7 gp4-like protein with intramitochondrial nucleoid localization|T7 helicase-related protein with intramitochondrial nucleoid localization|T7-like mitochondrial DNA helicase|ataxin 8|mitochondrial twinkle protein|progressive external ophthalmoplegia 1 protein|twinkle protein, mitochondrial
Swissprots	Q96RR0 Q96RR1 Q6PJP5 Q6MZX2 B2CQL2
Accessions	ACB21043 ADP92014 ADP92015 ADP92016 ADP92017 ADP92018 ADP92019 ADP92020 ADP92021 ADP92022 ADP92023 ADP92024 ADP92025 ADP92026 ADP92027 ADP92028 ADP92029 ADP92030 ADP92031 ADP92032 ADP92033 ADP92034 ADP92035 ADP92036 ADP92037 ADP92038 ADP92039 ADP92040 ADP92041 ADP92042 ADP92043 ADP92044 ADP92045 ADP92046 ADP92047 ADP92048 ADP92049 ADP92050 ADP92051 ADP92052 ADP92053 EAW49793 EAW49794 Q96RR1 AF292004 AAK69558 AF292005 AAK69559 AK022959 AK025485 BAB15148 AK297068 BAG59589 AK308098 BC013349 AAH13349 BC033762 AAH33762 BG473173 BQ643363 BX640829 CAE45905 CB112401 DB090322 XM_011539974 XP_011538276 XM_011539975 XP_011538277 XR_945788 NM_001163812 NP_001157284 NM_001163813 NP_001157285 NM_001163814 NP_001157286 NM_021830 NP_068602
Function	Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals. {ECO:0000269|PubMed:15167897}.
Subcellular Location	Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:11431692}. Note=Colocalizes with mtDNA in mitochondrial nucleoids, a nucleoproteins complex consisting of a number of copies of proteins associated with mtDNA, probably involved in mtDNA maintenance and expression.
Tissue Specificity	High relative levels in skeletal muscle, testis and pancreas. Lower levels of expression in the heart, brain, placenta, lung, liver, kidney, spleen, thymus, prostate, ovary, small intestine, colon and leukocytes. Expression is coregulated with MRPL43. {ECO:0000269|PubMed:11431692, ECO:0000269|PubMed:15509589}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Twinkle (T-20) - sc-55418 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Twinkle (H-300) - sc-134915 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Twinkle (D-16) - sc-55415 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Twinkle antibody - ab187517 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Twinkle antibody - ab83329 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Twinkle antibody - ab83207 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Twinkle antibody - C-terminal - ab170770 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-C10orf2 / PEO1 Antibody (aa656-684) - LS-C156913 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-C10orf2 / PEO1 Antibody - LS-C333968 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-C10orf2 / PEO1 Antibody (aa663-684, AP) - LS-C253001 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-C10orf2 / PEO1 Antibody (aa663-684, Biotin) - LS-C253003 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-C10orf2 / PEO1 Antibody (aa663-684, APC) - LS-C253002 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-C10orf2 / PEO1 Antibody (aa663-684, Azide-free, HRP) - LS-C253005 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-C10orf2 / PEO1 Antibody (aa663-684, FITC) - LS-C253004 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-C10orf2 / PEO1 Antibody (aa663-684, PE) - LS-C253007 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-C10orf2 / PEO1 Antibody (aa663-684) - LS-C319914 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-C10orf2 / PEO1 Antibody (aa540-589) - LS-C101632 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-C10orf2 / PEO1 Antibody (aa612-661) - LS-C101631 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-C10orf2 / PEO1 Antibody - LS-C341567 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-C10orf2 / PEO1 Antibody (C-Terminus) - LS-C345856 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

PEO1 Antibody - NBP1-57356 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PEO1 Antibody - NBP1-57355 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PEO1 Antibody - NBP1-90814 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PEO1 Antibody (1C5) - H00056652-M03 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1C5

Anti-PEO1 (ab2) antibody produced in rabbit - SAB2101772 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

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