Gene Symbol | cdc2 |
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Entrez Gene | 2539869 |
Alt Symbol | cdk1, swo2, tws1 |
Species | S. pombe |
Gene Type | protein-coding |
Description | cyclin-dependent protein kinase Cdk1/Cdc2 |
Other Description | - |
Swissprots | P04551 |
Accessions | CAC37513 P04551 NM_001021523 NP_595629 |
Function | Plays a key role in the control of the eukaryotic cell cycle. It is required for entry into S-phase and mitosis. When complexed with cig2, plays a role in G1-S phase transition. When activated and complexed with the cyclin cdc13, it leads to the onset of mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. Involved in cell cycle arrest induced by defective RNA splicing. Required for phosphorylation of dis1 to ensure accurate chromosome segregation and for the DNA damage checkpoint. {ECO:0000269|PubMed:16049013, ECO:0000269|PubMed:16920624, ECO:0000269|PubMed:8087848, ECO:0000269|PubMed:9042863}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16823372}. |
Top Pathways | Cell cycle - yeast, Meiosis - yeast |
Recombinant Schizosaccharomyces pombe Cyclin-dependent kinase 1(cdc2) - CSB-YP361294SXV CSB-EP361294SXV CSB-BP361294SXV CSB-MP361294SXV from Cusabio
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Cyclin-dependent kinase 1 (cdc2), Recombinant Protein - MBS1058810 from MyBioSource
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