| Gene Symbol |
FAM111A
|
| Entrez Gene |
63901
|
| Alt Symbol |
GCLEB, KCS2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
family with sequence similarity 111, member A
|
| Other Description |
protein FAM111A
|
| Swissprots |
Q9H5Y1 Q6IPR7 Q68DK9 A8K5Y8 Q5XKM2 Q96PZ2 Q5RKS9
|
| Accessions |
EAW73834 EAW73835 EAW73836 EAW73837 Q96PZ2 AB067482 BAB67788 AK025319 AK026447 BAB15486 AK092061 AK092237 AK092953 AK130799 AK291453 BAF84142 BC013137 AAH13137 BC041693 BC054515 AAH54515 BC071759 AAH71759 BQ420366 BU428612 CR747277 CR749358 CAH18211 DA502464 DB218857 NM_001142519 NP_001135991 NM_001142520 NP_001135992 NM_001142521 NP_001135993 NM_022074 NP_071357 NM_198847 NP_942144
|
| Function |
Chromatin-associated protein required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis (PubMed:24561620). May directly function at replication forks, explaining why Simian virus 40 (SV40) interacts with FAM111A to overcome host range restriction (PubMed:23093934). {ECO:0000269|PubMed:23093934, ECO:0000269|PubMed:24561620}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Mainly localizes to nucleus: colocalizes with PCNA on replication sites. {ECO:0000269|PubMed:24561620}.
|