Gene Symbol | BCAT1 |
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Entrez Gene | 586 |
Alt Symbol | BCATC, BCT1, ECA39, MECA39, PNAS121, PP18 |
Species | Human |
Gene Type | protein-coding |
Description | branched chain amino-acid transaminase 1, cytosolic |
Other Description | branched chain aminotransferase 1, cytosolic|branched-chain-amino-acid aminotransferase, cytosolic|placental protein 18 |
Swissprots | Q96MY9 Q68DQ7 B3KY27 B7Z5L0 F5H5E4 B7Z2M5 P54687 |
Accessions | EAW96497 EAW96498 EAW96499 P54687 AA376058 AF277179 AK024923 AK025615 AK056255 BAB71129 AK128527 BAG54689 AK294879 BAH11911 AK299088 BAH12946 BC026006 BC033864 BM458559 BU618839 BU730066 BX474651 BX647122 CR749308 CAH18163 DC385021 U21551 AAB08528 XM_011520810 XP_011519112 NM_001178091 NP_001171562 NM_001178092 NP_001171563 NM_001178093 NP_001171564 NM_001178094 NP_001171565 NM_005504 NP_005495 |
Function | Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma. |
Top Pathways | Valine, leucine and isoleucine biosynthesis, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism, Valine, leucine and isoleucine degradation, Pantothenate and CoA biosynthesis |
ECA39 CRISPR/Cas9 KO Plasmid (h) - sc-417673 from Santa Cruz Biotechnology
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ECA39 HDR Plasmid (h) - sc-417673-HDR from Santa Cruz Biotechnology
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ECA39 Double Nickase Plasmid (h) - sc-417673-NIC from Santa Cruz Biotechnology
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ECA39 Double Nickase Plasmid (h2) - sc-417673-NIC-2 from Santa Cruz Biotechnology
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ECA39 CRISPR Activation Plasmid (h) - sc-417673-ACT from Santa Cruz Biotechnology
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ECA39 CRISPR Activation Plasmid (h2) - sc-417673-ACT-2 from Santa Cruz Biotechnology
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ECA39 Lentiviral Activation Particles (h) - sc-417673-LAC from Santa Cruz Biotechnology
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ECA39 Lentiviral Activation Particles (h2) - sc-417673-LAC-2 from Santa Cruz Biotechnology
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ECA39 siRNA (h) - sc-77222 from Santa Cruz Biotechnology
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ECA39 shRNA Plasmid (h) - sc-77222-SH from Santa Cruz Biotechnology
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ECA39 shRNA (h) Lentiviral Particles - sc-77222-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU072291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3896 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3896 from Sigma-Aldrich
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BCAT1 siRNA (Human) - CRH0403 from Cohesion Biosciences
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BCAT1 - MBS8232009 from MyBioSource
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shRNA set against Human BCAT1 (NM_005504.6) - SHH245750 from Creative biogene
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Human BCAT1 siRNA - orb260905 from Biorbyt
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BCAT1 shRNA Plasmid (Human) - CHH0403 from Cohesion Biosciences
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