Gene Symbol | LIG1 |
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Entrez Gene | 3978 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | ligase I, DNA, ATP-dependent |
Other Description | DNA ligase 1|polydeoxyribonucleotide synthase [ATP] 1 |
Swissprots | Q2TB12 P18858 B2RAI8 Q32P23 B4DTU4 |
Accessions | AAM77697 BAC81763 EAW52316 EAW52317 P18858 AB208791 BAD92028 AK225863 AK297296 BAG59764 AK300370 BAG62106 AK300607 BAG62303 AK303644 BAG64647 AK314210 BAG36885 BC108318 AAI08319 BC110622 AAI10623 M36067 AAA59518 XM_005258934 XP_005258991 XM_006723215 XP_006723278 XM_006723216 XP_006723279 XR_243932 XR_430200 NM_000234 NP_000225 NM_001289063 NP_001275992 NM_001289064 NP_001275993 NR_110296 |
Function | DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. |
Subcellular Location | Nucleus. |
Top Pathways | DNA replication, Mismatch repair, Base excision repair, Nucleotide excision repair |
DNA Ligase I CRISPR/Cas9 KO Plasmid (h) - sc-402830 from Santa Cruz Biotechnology
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DNA Ligase I HDR Plasmid (h) - sc-402830-HDR from Santa Cruz Biotechnology
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DNA Ligase I Double Nickase Plasmid (h) - sc-402830-NIC from Santa Cruz Biotechnology
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DNA Ligase I Double Nickase Plasmid (h2) - sc-402830-NIC-2 from Santa Cruz Biotechnology
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DNA Ligase I CRISPR Activation Plasmid (h) - sc-402830-ACT from Santa Cruz Biotechnology
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DNA Ligase I CRISPR Activation Plasmid (h2) - sc-402830-ACT-2 from Santa Cruz Biotechnology
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DNA Ligase I Lentiviral Activation Particles (h) - sc-402830-LAC from Santa Cruz Biotechnology
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DNA Ligase I Lentiviral Activation Particles (h2) - sc-402830-LAC-2 from Santa Cruz Biotechnology
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DNA Ligase I siRNA (h) - sc-35198 from Santa Cruz Biotechnology
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DNA Ligase I shRNA Plasmid (h) - sc-35198-SH from Santa Cruz Biotechnology
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DNA Ligase I shRNA (h) Lentiviral Particles - sc-35198-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU153921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11703 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11703 from Sigma-Aldrich
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LIG1 siRNA (Human) - CRH2692 from Cohesion Biosciences
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DNA Ligase I RNAi - H00003978-R01 from Novus Biologicals
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shRNA set against Human LIG1 (NM_000234.1) - SHH330227 from Creative biogene
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shRNA set against Human LIG1(NM_000234.1) - SHH149195 from Creative biogene
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LIG1 shRNA Plasmid (Human) - CHH2692 from Cohesion Biosciences
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LIG1 miRNA 3'UTR clone - MiUTR1H-05667 from Creative biogene
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