Gene Symbol |
ANAPC5
|
Entrez Gene |
51433
|
Alt Symbol |
APC5
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
anaphase promoting complex subunit 5
|
Other Description |
anaphase-promoting complex subunit 5|cyclosome subunit 5
|
Swissprots |
E9PFB2 Q9UJX4 Q9BQD4 Q8N4H7
|
Accessions |
EAW98259 EAW98260 EAW98261 Q9UJX4 AA349724 AF191339 AAF05753 AI879332 AK025614 AK054779 BAG51422 AK294139 BAG57465 AK301197 BAH13429 AK315451 BC001081 AAH01081 BC001950 AAH01950 BC003095 BC006301 AAH06301 BC034243 AAH34243 BC045686 AAH45686 BX381618 BX537687 CAD97812 XM_005253900 XP_005253957 XM_006719449 XP_006719512 NM_001137559 NP_001131031 NM_016237 NP_057321
|
Function |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.
|
Top Pathways |
Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection
|