Kl

Gene Symbol Kl
Entrez Gene 16591
Alt Symbol alpha-kl
Species Mouse
Gene Type protein-coding
Description klotho
Other Description secreted form of Klotho protein
Swissprots O70621 O70175 O35082 B2RR78
Accessions BAA25308 BAA25309 EDL05885 EDL05886 O35082 AB005141 BAA23381 AB010088 BAA25307 AK134616 BAE22211 BC138258 AAI38259 BC138259 AAI38260 XM_006504917 XP_006504980 XM_006504951 XP_006505014 NM_013823 NP_038851
Function May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1.
Subcellular Location Klotho peptide: Secreted.
Tissue Specificity Membrane-bound protein is present in distal renal tubules, inner ear, ependymal cells of brain choroid plexus, elongating spermatids and mature oocytes (at protein level). Soluble peptide is present in serum (100 pM) and cerebrospinal fluid. Expressed strongly in kidney, moderately in brain choroid plexus, and at low levels in pituitary, placenta, skeletal muscle, urinary bladder, aorta, pancreas, testis, ovary, colon, thyroid gland and adipocytes. {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:11411791, ECO:0000269|PubMed:12204354, ECO:0000269|PubMed:15135068, ECO:0000269|PubMed:15665504, ECO:0000269|PubMed:16123266, ECO:0000269|PubMed:9363890, ECO:0000269|PubMed:9537505}.
Top Pathways Endocrine and other factor-regulated calcium reabsorption, Pentose and glucuronate interconversions, Starch and sucrose metabolism

Klotho (27Y-1) - sc-74205 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rat
Clonality Monoclonal
Klotho (27Y-1): sc-74205. Western blot analysis of Klotho expression in mouse liver (A) and mouse small intestine (B) tissue extracts.

Anti-Klotho antibody - ab154163 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Klotho antibody (ab154163) at 1 µg/mlLane 1 : Wild Type (WT) Mouse Kidney Tissue LysateLane 2 : Knock Out (KO) Mouse Kidney Tissue LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Klotho antibody [RM0119-4F54] - ab86794 from Abcam

Prices $370.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone RM0119-4F54

Klotho Antibody - AF1819 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Klotho was detected in perfusion fixed frozen sections of mouse kidney using 1.7 µg/mL Mouse Klotho Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1819) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Klotho Antibody [Biotin] - BAF1819 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-KL antibody produced in rabbit - SAB2106397 from Sigma-Aldrich

Prices $341.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-KL: <B>Cat. No. SAB2106397</B>: Western blot analysis of Kl in Mouse Small Intestine with Kl (klotho) antibody against the N terminal of Kl (50 μg) antibody at 1.0 μg/mL.

Kl antibody - N-terminal region (ARP36671_P050) - ARP36671_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Klotho antibody - GTX18131 from GeneTex

Prices $319.00
Sizes 25 μg
Host Rabbit
Clonality Polyclonal

Klotho antibody [4F54] - GTX53209 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rat
Clonality Monoclonal
Clone 4F54

Anti -Klotho (KL) - K1893-01 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Klotho (KL) - K1893-02 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Klotho (KL) - K1893-01L from USBiological Life Science

Host Rat
Clonality Monoclonal
Clone 7C39

Anti -Klotho (KL) - 141181 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Klotho (KL) - 141182 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Klotho (KL) - 216770 from USBiological Life Science

Host Rat
Clonality Monoclonal
Clone 14L674

Anti -Klotho (KL) (AP) - 141181-AP from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Klotho (KL) (AP) - 141182-AP from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Klotho (KL) (APC) - 141181-APC from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Klotho (KL) (APC) - 141182-APC from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Klotho (KL) (Biotin) - 141181-Biotin from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Klotho (KL) (Biotin) - 141182-Biotin from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Klotho (KL) (FITC) - 141181-FITC from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Klotho (KL) (FITC) - 141182-FITC from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Klotho (KL) (HRP) - 141181-HRP from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Anti -Klotho (KL) (HRP) - 141182-HRP from USBiological Life Science

Host Rabbit
Clonality Polyclonal
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