| Gene Symbol | Kl |
|---|---|
| Entrez Gene | 16591 |
| Alt Symbol | alpha-kl |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | klotho |
| Other Description | secreted form of Klotho protein |
| Swissprots | O70621 O70175 O35082 B2RR78 |
| Accessions | BAA25308 BAA25309 EDL05885 EDL05886 O35082 AB005141 BAA23381 AB010088 BAA25307 AK134616 BAE22211 BC138258 AAI38259 BC138259 AAI38260 XM_006504917 XP_006504980 XM_006504951 XP_006505014 NM_013823 NP_038851 |
| Function | May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1. |
| Subcellular Location | Klotho peptide: Secreted. |
| Tissue Specificity | Membrane-bound protein is present in distal renal tubules, inner ear, ependymal cells of brain choroid plexus, elongating spermatids and mature oocytes (at protein level). Soluble peptide is present in serum (100 pM) and cerebrospinal fluid. Expressed strongly in kidney, moderately in brain choroid plexus, and at low levels in pituitary, placenta, skeletal muscle, urinary bladder, aorta, pancreas, testis, ovary, colon, thyroid gland and adipocytes. {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:11411791, ECO:0000269|PubMed:12204354, ECO:0000269|PubMed:15135068, ECO:0000269|PubMed:15665504, ECO:0000269|PubMed:16123266, ECO:0000269|PubMed:9363890, ECO:0000269|PubMed:9537505}. |
| Top Pathways | Endocrine and other factor-regulated calcium reabsorption, Pentose and glucuronate interconversions, Starch and sucrose metabolism |