Gene Symbol | ACAD9 |
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Entrez Gene | 28976 |
Alt Symbol | NPD002 |
Species | Human |
Gene Type | protein-coding |
Description | acyl-CoA dehydrogenase family, member 9 |
Other Description | acyl-CoA dehydrogenase family member 9, mitochondrial|acyl-Coenzyme A dehydrogenase family, member 9|very-long-chain acyl-CoA dehydrogenase VLCAD |
Swissprots | D3DNB8 Q8WXX3 Q9H845 |
Accessions | EAW79293 EAW79294 EAW79295 EAW79296 Q9H845 AB209427 BAD92664 AF078854 AAD44486 AF327351 AAL56011 AK022568 BAB14104 AK024012 BAB14775 AK027186 AK130311 AK294597 BAG57785 AK297952 BAG60267 AK310644 BC001817 AAH01817 BC007970 AAH07970 BC013354 AAH13354 BC041572 DA630022 DQ893516 ABM84442 DQ896495 ABM87494 XM_011512742 XP_011511044 XR_427367 NM_014049 NP_054768 NR_033426 |
Function | Required for mitochondrial complex I assembly (PubMed:20816094, PubMed:24158852). Has a dehydrogenase activity on palmitoyl-CoA (C16:0) and stearoyl-CoA (C18:0). It is three times more active on palmitoyl-CoA than on stearoyl-CoA. However, it does not play a primary role in long-chain fatty acid oxidation in vivo (PubMed:20816094, PubMed:24158852). Has little activity on octanoyl-CoA (C8:0), butyryl-CoA (C4:0) or isovaleryl-CoA (5:0). {ECO:0000269|PubMed:20816094, ECO:0000269|PubMed:24158852}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:20816094}. |
Tissue Specificity | Ubiquitously expressed in most normal human tissues and cancer cell lines with high level of expression in heart, skeletal muscles, brain, kidney and liver. {ECO:0000269|PubMed:12359260}. |
ACAD-9 CRISPR/Cas9 KO Plasmid (h) - sc-412013 from Santa Cruz Biotechnology
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ACAD-9 HDR Plasmid (h) - sc-412013-HDR from Santa Cruz Biotechnology
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ACAD-9 Double Nickase Plasmid (h) - sc-412013-NIC from Santa Cruz Biotechnology
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ACAD-9 Double Nickase Plasmid (h2) - sc-412013-NIC-2 from Santa Cruz Biotechnology
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ACAD-9 CRISPR Activation Plasmid (h) - sc-412013-ACT from Santa Cruz Biotechnology
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ACAD-9 CRISPR Activation Plasmid (h2) - sc-412013-ACT-2 from Santa Cruz Biotechnology
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ACAD-9 Lentiviral Activation Particles (h) - sc-412013-LAC from Santa Cruz Biotechnology
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ACAD-9 Lentiviral Activation Particles (h2) - sc-412013-LAC-2 from Santa Cruz Biotechnology
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ACAD-9 siRNA (h) - sc-61935 from Santa Cruz Biotechnology
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ACAD-9 shRNA Plasmid (h) - sc-61935-SH from Santa Cruz Biotechnology
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ACAD-9 shRNA (h) Lentiviral Particles - sc-61935-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU077941 from Sigma-Aldrich
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MISSION® esiRNA - EHU118911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2690 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2690 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04425 from Sigma-Aldrich
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ACAD9 siRNA (Human) - CRH9141 from Cohesion Biosciences
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ACAD9 - MBS8240931 from MyBioSource
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shRNA set against Human ACAD9 (NM_014049.4) - SHH229902 from Creative biogene
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ACAD9 shRNA Plasmid (Human) - CHH9141 from Cohesion Biosciences
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ACAD9 miRNA 3'UTR clone - MiUTR3H-11657 from Creative biogene
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