| Gene Symbol | Acsl1 |
|---|---|
| Entrez Gene | 25288 |
| Alt Symbol | ACS, Acas, COAA, Facl2 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | acyl-CoA synthetase long-chain family member 1 |
| Other Description | Acyl CoA synthetase, long chain|LACS 1|fatty acid Coenzyme A ligase, long chain 2|long-chain acyl-CoA synthetase 1|long-chain-fatty-acid--CoA ligase 1|long-chain-fatty-acid--CoA ligase, liver isozyme |
| Swissprots | P18163 |
| Accessions | CBF64918 CBU89789 EDL78886 EDL78887 EDL78888 EDL78889 P18163 D90109 BAA14136 FQ214802 FQ217275 FQ219468 XM_006253122 XP_006253184 XM_006253123 XP_006253185 XM_006253124 XP_006253186 XM_006253125 XP_006253187 XM_006253126 XP_006253188 XM_006253127 XP_006253189 XM_008771254 XP_008769476 NM_012820 NP_036952 |
| Function | Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses oleate, arachidonate, eicosapentaenoate and docosahexaenoate as substrates. |
| Subcellular Location | Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. |
| Tissue Specificity | Liver, heart, epididymal adipose and to a lesser extent brain, small intestine and lung. |
| Top Pathways | Adipocytokine signaling pathway, PPAR signaling pathway, Peroxisome, Fatty acid biosynthesis, Fatty acid degradation |