| Gene Symbol |
Acsl1
|
| Entrez Gene |
25288
|
| Alt Symbol |
ACS, Acas, COAA, Facl2
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
acyl-CoA synthetase long-chain family member 1
|
| Other Description |
Acyl CoA synthetase, long chain|LACS 1|fatty acid Coenzyme A ligase, long chain 2|long-chain acyl-CoA synthetase 1|long-chain-fatty-acid--CoA ligase 1|long-chain-fatty-acid--CoA ligase, liver isozyme
|
| Swissprots |
P18163
|
| Accessions |
CBF64918 CBU89789 EDL78886 EDL78887 EDL78888 EDL78889 P18163 D90109 BAA14136 FQ214802 FQ217275 FQ219468 XM_006253122 XP_006253184 XM_006253123 XP_006253185 XM_006253124 XP_006253186 XM_006253125 XP_006253187 XM_006253126 XP_006253188 XM_006253127 XP_006253189 XM_008771254 XP_008769476 NM_012820 NP_036952
|
| Function |
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses oleate, arachidonate, eicosapentaenoate and docosahexaenoate as substrates.
|
| Subcellular Location |
Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Liver, heart, epididymal adipose and to a lesser extent brain, small intestine and lung.
|
| Top Pathways |
Adipocytokine signaling pathway, PPAR signaling pathway, Peroxisome, Fatty acid biosynthesis, Fatty acid degradation
|