Gene Symbol | Lias |
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Entrez Gene | 79464 |
Alt Symbol | 2900022L22Rik, 4933425M12Rik, 7a5ex, C77512, mLip1 |
Species | Mouse |
Gene Type | protein-coding |
Description | lipoic acid synthetase |
Other Description | LS|lip-syn|lipoate synthase|lipoic acid synthase|lipoyl synthase, mitochondrial |
Swissprots | Q99M04 Q543M1 |
Accessions | CBN72488 EDL37739 EDL37740 Q99M04 AB057731 BAB62009 AK013575 AK031851 BAC27579 AK045167 AK048744 BAC33443 AK049548 BAC33804 AK077192 BAC36672 BC002141 AAH02141 XM_006504194 XP_006504257 XM_006504195 XP_006504258 NM_024471 NP_077791 |
Function | Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000305}. |
Subcellular Location | Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03123, ECO:0000269|PubMed:11389890}. |
Tissue Specificity | Expressed predominantly in heart, testis, and liver. {ECO:0000269|PubMed:11389890}. |
Top Pathways | Lipoic acid metabolism |
Recombinant Mouse Lipoyl synthase, mitochondrial(Lias) - CSB-YP860388MO CSB-EP860388MO CSB-BP860388MO CSB-MP860388MO from Cusabio
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Recombinant Mouse LIAS Protein - LIAS-9093M from Creative Biomart
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Lipoyl synthase, mitochondrial (Lias), Recombinant Protein - MBS1474501 from MyBioSource
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