Gene Symbol | SLC29A1 |
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Entrez Gene | 2030 |
Alt Symbol | ENT1 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 29 (equilibrative nucleoside transporter), member 1 |
Other Description | equilibrative NBMPR-sensitive nucleoside transporter|equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporter|equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter|equilibrative nucleoside transporter 1|nucleoside transporter, es-type|solute carrier family 29 (nucleoside transporters), member 1|solute carrier family 29 member 1|solute carrier family 29, member 1 |
Swissprots | Q9UJY2 Q5T9W9 B3KQY5 B3KQV7 Q99808 |
Accessions | AAF02777 AAM11785 EAX04254 EAX04255 EAX04256 Q99808 AB490708 BAI39492 AB490709 BAI39493 AF079117 AAC62495 AK090491 BAG52169 AK090615 BAG52197 AK293558 BAH11534 AK304285 BAH14150 AX775997 CAE11698 BC001382 AAH01382 BC008954 AAH08954 BC095398 BM661584 CB996332 DA559201 DA680982 DC396448 DQ892133 ABM83059 DQ895327 ABM86253 U81375 AAC51103 XM_005248876 XP_005248933 XM_005248878 XP_005248935 XM_005248879 XP_005248936 XM_005248880 XP_005248937 XM_005248881 XP_005248938 XM_005248882 XP_005248939 XM_011514341 XP_011512643 NM_001078177 NP_001071645 NM_001304462 NP_001291391 NM_001304463 NP_001291392 NM_001304465 NP_001291394 NM_001304466 NP_001291395 NM_001078174 NM_001078176 NM_004955 NM_001078175 NP_001071643 |
Function | Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs). |
Subcellular Location | Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells. |
Tissue Specificity | Detected in erythrocytes (at protein level). Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen. {ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:23219802}. |
Top Pathways | Alcoholism |
Human ENT1 full length protein - ab152365 from Abcam
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Human ENT1 peptide - ab48606 from Abcam
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SLC29A1 / ENT1 Antibody Blocking Peptide - LS-E565 from LifeSpan Bioscience
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SLC29A1 / ENT1 Antibody Blocking Peptide - LS-E566 from LifeSpan Bioscience
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SLC29A1 / ENT1 Antibody Blocking Peptide - LS-E567 from LifeSpan Bioscience
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SLC29A1 / ENT1 Antibody Blocking Peptide - LS-E29516 from LifeSpan Bioscience
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SLC29A1 / ENT1 Antibody Blocking Peptide - LS-E29517 from LifeSpan Bioscience
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SLC29A1 / ENT1 Antibody Blocking Peptide - LS-E29518 from LifeSpan Bioscience
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SLC29A1 / ENT1 Antibody Blocking Peptide - LS-E7440 from LifeSpan Bioscience
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SLC29A1 / ENT1 Antibody Blocking Peptide - LS-E29755 from LifeSpan Bioscience
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Recombinant Human ENT1 Protein - H00002030-P01 from Novus Biologicals
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ENT1 Peptide - P0205 from Novus Biologicals
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ENT1Slc29a1-Antibody-S254-Blocking-Peptide - BP1086d from Abgent, a WuXi AppTec company
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ENT1-Antibody-Center-Blocking-Peptide - BP1086c from Abgent, a WuXi AppTec company
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ENT1-Antibody-C-term-Blocking-Peptide - BP1086b from Abgent, a WuXi AppTec company
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Phospho-ENT1Slc29a1S254-Antibody-Blocking-peptide - BP3615a from Abgent, a WuXi AppTec company
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SLC29A1 peptide - orb217251 from Biorbyt
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ENT1 Blocking Peptide - abx062582 from Abbexa
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SLC29A1 - H00002030-P01 from Acris Antibodies
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SLC29A1 / ENT1 - H00002030-P01-10 from Acris Antibodies
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SLC29A1 / ENT1 - H00002030-P01-25 from Acris Antibodies
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SLC29A1 Peptide - 8125P from ProSci
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ENT1 fusion protein - Ag1881 from Proteintech Group
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ENT1 Blocking Peptide - CBP1388 from Cohesion Biosciences
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SLC29A1 Peptide - BS5712P from Bioworld Technology
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