| Gene Symbol |
Bmx
|
| Entrez Gene |
12169
|
| Alt Symbol |
Etk, Etk/Bmx, Tyro8
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
BMX non-receptor tyrosine kinase
|
| Other Description |
TYRO8 protein tyrosine kinase 8|bone marrow tyrosine kinase gene in chromosome X protein homolog|cytoplasmic tyrosine-protein kinase BMX
|
| Swissprots |
P97504
|
| Accessions |
EDL40760 P97504 AF012104 AAC53370 AK036707 BAC29542 AK040936 BAC30753 AK080038 BAC37811 BC138104 AAI38105 BC138105 AAI38106 U88091 AAB47770 NM_009759 NP_033889
|
| Function |
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Note=Localizes to the edges of spreading cells when complexed with BCAR1. {ECO:0000250}.
|
| Tissue Specificity |
Specifically expressed in the endocardium of the developing heart as well as in the endocardium of the left ventricle and in the endothelium of large arteries in adult mice. {ECO:0000269|PubMed:9323053}.
|