| Gene Symbol |
COMT
|
| Entrez Gene |
100155530
|
| Alt Symbol |
-
|
| Species |
Pig
|
| Gene Type |
protein-coding
|
| Description |
catechol-O-methyltransferase
|
| Other Description |
catechol O-methyltransferase
|
| Swissprots |
Q99028
|
| Accessions |
GU373691 ADC38891 XM_005670936 XP_005670993 XM_005670937 XP_005670994 NM_001195330 NP_001182259
|
| Function |
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}.
|
| Top Pathways |
Steroid hormone biosynthesis, Dopaminergic synapse, Tyrosine metabolism
|