Gene Symbol | SOD1 |
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Entrez Gene | 6647 |
Alt Symbol | ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer |
Species | Human |
Gene Type | protein-coding |
Description | superoxide dismutase 1, soluble |
Other Description | Cu/Zn superoxide dismutase|SOD, soluble|epididymis secretory protein Li 44|indophenoloxidase A|superoxide dismutase [Cu-Zn]|superoxide dismutase, cystolic |
Swissprots | Q16711 P00441 Q6NR85 Q16840 Q16669 A6NHJ0 Q16839 Q16838 D3DSE4 |
Accessions | AAB05661 AAB05662 AAB59626 AAB59627 AAC41773 AAV80422 AHL39099 AHW49383 AHW49384 AHW49385 AHW49386 AHW49387 AHW49388 CAA25915 CAA25916 CAA25917 CAA25918 CAA25919 CAA64520 CBX86766 CCQ42983 EAX09889 EAX09890 P00441 AK312116 BAG35052 AV756797 AY049787 AAL15444 AY450286 AAR21563 BC001034 AAH01034 BT006676 AAP35322 CA448539 CR450355 CAG29351 CR541742 CAG46542 EF143990 ABL96474 EF151142 ABL96616 EU794661 ACJ13715 W17182 X02317 CAA26182 NM_000454 NP_000445 |
Function | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. |
Subcellular Location | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria. |
Top Pathways | Amyotrophic lateral sclerosis (ALS), Huntington's disease, Prion diseases, Peroxisome |
SOD-1 CRISPR/Cas9 KO Plasmid (h) - sc-400186 from Santa Cruz Biotechnology
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SOD-1 HDR Plasmid (h) - sc-400186-HDR from Santa Cruz Biotechnology
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SOD-1 Double Nickase Plasmid (h) - sc-400186-NIC from Santa Cruz Biotechnology
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SOD-1 Double Nickase Plasmid (h2) - sc-400186-NIC-2 from Santa Cruz Biotechnology
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SOD-1 CRISPR Activation Plasmid (h) - sc-400186-ACT from Santa Cruz Biotechnology
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SOD-1 CRISPR Activation Plasmid (h2) - sc-400186-ACT-2 from Santa Cruz Biotechnology
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SOD-1 Lentiviral Activation Particles (h) - sc-400186-LAC from Santa Cruz Biotechnology
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SOD-1 Lentiviral Activation Particles (h2) - sc-400186-LAC-2 from Santa Cruz Biotechnology
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SOD-1 siRNA (h) - sc-36523 from Santa Cruz Biotechnology
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SOD-1 shRNA Plasmid (h) - sc-36523-SH from Santa Cruz Biotechnology
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SOD-1 shRNA (h) Lentiviral Particles - sc-36523-V from Santa Cruz Biotechnology
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SOD1/Cu-Zn SOD RNAi - H00006647-R01 from Novus Biologicals
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MISSION® esiRNA - EHU050511 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1713 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1713 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12102 from Sigma-Aldrich
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SOD1 siRNA (Human) - CRH4527 from Cohesion Biosciences
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SOD1 - MBS8229272 from MyBioSource
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shRNA set against Human SOD1 (NM_000454.4) - SHH415020 from Creative biogene
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shRNA set against Human SOD1(NM_000454.4) - SHL024474 from Creative biogene
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Human SOD1 siRNA - orb265029 from Biorbyt
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SOD1 shRNA Plasmid (Human) - CHH4527 from Cohesion Biosciences
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SOD1 miRNA 3'UTR clone - MiUTR1H-09736 from Creative biogene
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