| Gene Symbol | STK33 |
|---|---|
| Entrez Gene | 65975 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | serine/threonine kinase 33 |
| Other Description | serine/threonine-protein kinase 33 |
| Swissprots | Q9BYT3 Q8NEF5 Q658S6 |
| Accessions | CAD38243 CCQ43739 EAW68623 EAW68624 EAW68625 Q9BYT3 AJ303380 CAC29064 AK092720 BAG52601 AK093251 BAC04109 AK122808 AK293193 BAG56733 AK310754 AL833011 CAH56302 BC031231 AAH31231 BG722074 BU580591 DA348768 DB049619 DQ891517 ABM82443 EU176614 ABW03415 XM_011520288 XP_011518590 XM_011520289 XP_011518591 XM_011520290 XP_011518592 XM_011520291 XP_011518593 XM_011520292 XP_011518594 XM_011520293 XP_011518595 XM_011520294 XP_011518596 XM_011520295 XP_011518597 XM_011520296 XP_011518598 XM_011520297 XP_011518599 XM_011520298 XP_011518600 XR_428847 NM_001289058 NP_001275987 NM_001289059 NP_001275988 NM_001289061 NP_001275990 NM_030906 NP_112168 |
| Function | Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines. {ECO:0000250, ECO:0000269|PubMed:21742770}. |
| Subcellular Location | Cytoplasm, perinuclear region {ECO:0000250}. |
| Tissue Specificity | Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney, interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed in the following tissues: amygdala, aorta, esophagus, colon ascending, colon transverse, skeletal muscle, spleen, peripheral blood leukocyte, lymph node, bone marrow, placenta, prostate, liver, salivary gland, mammary gland, some tumor cell lines, fetal brain, fetal liver, fetal spleen and fetal thymus. No signal at all was detectable in RNA from tissues of the nervous system. {ECO:0000269|PubMed:11738831, ECO:0000269|PubMed:16176263}. |