MAP2K6
| Gene Symbol | MAP2K6 |
|---|---|
| Entrez Gene | 5608 |
| Alt Symbol | MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase kinase 6 |
| Other Description | MAPK/ERK kinase 6|MAPKK 6|MEK 6|SAPK kinase 3|dual specificity mitogen-activated protein kinase kinase 6|protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)|stress-activated protein kinase kinase 3 |
| Swissprots | P52564 |
| Accessions | ABY87539 AGC09595 EAW89084 EAW89085 EAW89086 P52564 AA932919 AB451252 BAG70066 AB451376 BAG70190 AK225719 AK290747 BAF83436 BC012009 AAH12009 BX641121 CAE46056 D87905 BAA13496 DB111443 DQ891488 ABM82414 DQ894673 ABM85599 U39064 AAB03708 U39065 AAB03705 U39656 AAC50388 U39657 AAC50389 U49732 AAB05035 X96757 CAA65532 XM_005257515 XP_005257572 XM_005257516 XP_005257573 XM_006721975 XP_006722038 XM_011525025 XP_011523327 XM_011525026 XP_011523328 XM_011525027 XP_011523329 NM_002758 NP_002749 NM_031988 |
| Function | Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regul |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:9768359}. Cytoplasm {ECO:0000269|PubMed:9768359}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9768359}. Note=Binds to microtubules. |
| Tissue Specificity | Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas. {ECO:0000269|PubMed:8621675}. |
| Top Pathways | Osteoclast differentiation, TNF signaling pathway, Inflammatory mediator regulation of TRP channels, Epstein-Barr virus infection, Rap1 signaling pathway |
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