KIT

Gene Symbol	KIT
Entrez Gene	3815
Alt Symbol	C-Kit, CD117, PBT, SCFR
Species	Human
Gene Type	protein-coding
Description	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Other Description	mast/stem cell growth factor receptor Kit|p145 c-kit|piebald trait protein|proto-oncogene c-Kit|proto-oncogene tyrosine-protein kinase Kit|soluble KIT variant 1|tyrosine-protein kinase Kit|v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Swissprots	Q99662 P10721 D5LXN2 B5A956 Q6IQ28 F5H8F8 D5M931 Q9UM99
Accessions	AAB29301 AAB29529 AAC50968 AAC50969 ACI16424 ACI24886 CAA46771 CAA46772 CAA49159 CAJ15130 CAM35390 CAM91185 CAT16960 EAX05460 EAX05461 P10721 AJ438313 CAD27356 AK304031 BAG64945 BC071593 AAH71593 CN414753 DC376760 EU826594 ACF47630 GU983671 ADF36702 HM015525 ADF50068 HM015526 ADF50069 HM030712 ADF50070 HM030713 ADF50071 HM437240 ADN43071 X06182 CAA29548 XM_005265740 XP_005265797 XM_005265741 XP_005265798 XM_005265742 XP_005265799 NM_000222 NP_000213 NM_001093772 NP_001087241
Function	Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT p
Subcellular Location	Isoform 3: Cytoplasm. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head.
Tissue Specificity	Isoform 1 and isoform 2 are detected in spermatogonia and Leydig cells. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa (at protein level). Widely expressed. Detected in the hematopoietic system, the gastrointestinal system, in melanocytes and in germ cells. {ECO:0000269|PubMed:20601678, ECO:0000269|PubMed:2448137}.
Top Pathways	Rap1 signaling pathway, Cytokine-cytokine receptor interaction, Central carbon metabolism in cancer, PI3K-Akt signaling pathway, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

c-Kit CRISPR/Cas9 KO Plasmid (h) - sc-400106 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Kit HDR Plasmid (h) - sc-400106-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Kit Double Nickase Plasmid (h) - sc-400106-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Kit Double Nickase Plasmid (h2) - sc-400106-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Kit CRISPR Activation Plasmid (h) - sc-400106-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Kit CRISPR Activation Plasmid (h2) - sc-400106-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Kit Lentiviral Activation Particles (h) - sc-400106-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Kit Lentiviral Activation Particles (h2) - sc-400106-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

c-Kit siRNA (h) - sc-29225 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Kit shRNA Plasmid (h) - sc-29225-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

c-Kit shRNA (h) Lentiviral Particles - sc-29225-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU000841 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1032 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1031 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1030 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1554 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1554 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

KIT siRNA (Human) - CRH2584 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CD117/c-kit RNAi - H00003815-R04 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human KIT (NM_000222.2) - SHH325603 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human KIT(NM_000222.2) - SHL198378 from Creative biogene Category siRNA Species Reactivities Human

KIT shRNA Plasmid (Human) - CHH2584 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

KIT miRNA 3'UTR clone - MiUTR1H-05342 from Creative biogene Species Reactivities Human

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